{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:12:45Z","timestamp":1789567965747,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Neurointerventional procedures can deliver high localised skin doses and may cause radiation\u2010induced cutaneous tissue reactions, yet the doses at which these occur have not been synthesised specifically for this setting. We systematically reviewed reported cutaneous reactions and associated radiation doses after fluoroscopy\u2010 or digital subtraction angiography\u2010guided cranial or spinal neurointerventional procedures. Following PRISMA 2020, Ovid MEDLINE, Embase, Scopus and the Cochrane Library were searched in April 2026; case reports, case series and observational studies reporting a cutaneous reaction and\/or a relevant skin dose were eligible. Screening and extraction were performed by two independent reviewers, and studies were appraised with the Joanna Briggs Institute checklists; findings were synthesised narratively, with cohort\u2010derived incidence reported separately from case\u2010level data. Twenty\u2010five studies (approximately 686 patients; 11 countries) were included. Alopecia\/epilation was the dominant reaction (21 studies); dermatitis\/erythema (4) and ulceration\/necrosis (2) were less frequent. Among cohorts, incidence ranged from approximately 5% to 56% and rose with skin dose and procedural complexity. Reported onset doses tracked established deterministic thresholds: temporary epilation clustered around the approximately 3\u2009Gy threshold, whereas erythema and ulceration occurred at higher, usually cumulative, doses, and epilation below approximately 2\u2009Gy was reported in radiosensitive patients. Alopecia appeared 2\u20135\u2009weeks after the procedure and ulceration months to years later. Dose metrics were inconsistent, and 4 of 25 studies reported no dose. Standardised reporting of peak skin dose and dose\u2010triggered, structured follow\u2010up is needed.<\/jats:p>","DOI":"10.1111\/1754-9485.70156","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T10:01:33Z","timestamp":1785405693000},"page":"561-572","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Radiation\u2010Induced Cutaneous Tissue Reactions in Neurointerventional Procedures: A Systematic Review of Reported Effects and Associated Dose Levels"],"prefix":"10.1111","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8029-9951","authenticated-orcid":false,"given":"Mohamed Khaldoun","family":"Badawy","sequence":"first","affiliation":[{"name":"Monash Radiology Monash Health  Clayton Victoria Australia"},{"name":"Department of Medical Imaging and Radiation Sciences Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3042-6540","authenticated-orcid":false,"given":"Fatimah","family":"Balasim","sequence":"additional","affiliation":[{"name":"Monash Radiology Monash Health  Clayton Victoria Australia"},{"name":"Discipline of Medical Radiation, School of Health and Biomedical Sciences RMIT University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9976-2158","authenticated-orcid":false,"given":"Caitlan","family":"De Hoedt","sequence":"additional","affiliation":[{"name":"Monash Radiology Monash Health  Clayton Victoria Australia"},{"name":"Discipline of Medical Radiation, School of Health and Biomedical Sciences RMIT University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0277-3758","authenticated-orcid":false,"given":"Mercer","family":"Kim","sequence":"additional","affiliation":[{"name":"Library Services Monash Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8797-762X","authenticated-orcid":false,"given":"Samuel Montgomery","family":"Lilli","sequence":"additional","affiliation":[{"name":"Monash Radiology Monash Health  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0884-8230","authenticated-orcid":false,"given":"Alice","family":"Gutowski","sequence":"additional","affiliation":[{"name":"Monash Radiology Monash Health  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"issue":"2","key":"e_1_2_11_2_1","first-page":"127","article-title":"Advances in the Endovascular Management of Cerebrovascular Disease","volume":"121","author":"Nunna R. 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