{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T09:06:13Z","timestamp":1789376773317,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100008719","name":"Movember Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008719","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We aimed to evaluate the adoption of hypofractionated radiotherapy (HFRT) for localised prostate cancer (PCa) and the quality of life (QOL) outcomes at a population\u2010based level in Victoria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a population\u2010based cohort of individuals with PCa registered in the Victorian Prostate Cancer Outcomes Registry (PCOR\u2010Vic) who had radiotherapy between 2016 and 2023. The primary outcomes were the proportion of individuals who had HFRT, and QOL 12\u2009months post\u2010treatment assessed using the EPIC26 questionnaire. Multivariable logistic regressions were used to evaluate factors associated with HFRT use, and linear regressions were used to estimate differences in EPIC26 domain scores between HFRT and conventional fractionated radiotherapy (CFRT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were 3647 individuals included in the study\u2014213 (6%) low\u2010risk PCa, 1799 (49%) intermediate\u2010risk PCa, and 1635 (45%) high\u2010risk PCa. There were 1729 (47%) individuals who had HFRT. The use of HFRT increased from 2% for the whole cohort\u00a0in 2016 to 87% for low\u2010intermediate risk PCa and 52% for high\u2010risk PCa in 2023. In multivariable analyses, increased age, low\u2010intermediate risk PCa, and more recent years of treatment were independently associated with treatment with HFRT. Among individuals who completed the 12\u2010month post\u2010treatment EPIC26 questionnaire, no statistically or clinically significant differences in urinary and bowel QOL outcomes were observed between HFRT and CFRT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There was a significant increase in the adoption of HFRT in this contemporaneous population\u2010based cohort of individuals who had radiotherapy for localised PCa in Victoria. At a population\u2010based level, there was no evidence of differences in QOL outcomes at 12\u2009months after HFRT and CFRT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1754-9485.70183","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T08:49:23Z","timestamp":1789375763000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adoption of Hypofractionated Radiation Therapy and Quality of Life Outcomes for Localised Prostate Cancer in an Australian Population\u2010Based Cohort"],"prefix":"10.1111","author":[{"given":"Therese Min Jung","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Andrew Love Cancer Centre Barwon Health  Geelong Victoria Australia"},{"name":"Bayside Health Radiation Oncology, School of Translational Medicine Monash University  Melbourne Victoria Australia"},{"name":"School of Public Health and Preventive 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Oncology University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1803-049X","authenticated-orcid":false,"given":"Sarat","family":"Chander","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Peter MacCallum Cancer Centre  Melbourne Victoria Australia"},{"name":"Sir Peter MacCallum Department of Oncology University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Ng","sequence":"additional","affiliation":[{"name":"Genesis Cancer Care Victoria  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9598-699X","authenticated-orcid":false,"given":"Jonathan","family":"Tomaszewski","sequence":"additional","affiliation":[{"name":"Ballarat Austin Radiation Oncology Centre Grampian Health  Ballarat Victoria 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