{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T15:06:24Z","timestamp":1789225584150,"version":"build-2803163510"},"reference-count":14,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:00:00Z","timestamp":1789171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:00:00Z","timestamp":1789171200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"abstract":"ABSTRACT<\/jats:title>\n \n Introduction<\/jats:title>\n In recent years, cervical cancer incidence has been on the decline in Australia, likely due to the HPV vaccination and an improved screening programme. However, an estimated 900 new cases will be diagnosed in 2025. The standard of care for locally advanced cervical cancer (LACC) is chemoradiotherapy, comprising external beam radiation therapy with concurrent cisplatin followed by image guided brachytherapy (IGBT), which is essential for optimal local control. Some patients will be ineligible for IGBT due to comorbidities, anaesthetic risk or technical challenges, with alternative EBRT boost techniques demonstrating higher toxicity and poorer patient outcomes. MR\u2010guided stereotactic body radiotherapy (MRg\u2010SBRT) offers improved soft tissue visualisation and daily adaptive planning, enabling accurate target coverage and reduced dose to organs at risk. MRg\u2010SBRT is an investigational non\u2010invasive boost option with emerging evidence supporting feasibility<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We describe our early experience treating four patients with cervical cancer who were ineligible for IGBT following pelvic EBRT \u00b1 chemotherapy. All patients completed treatment with adaptive MRg\u2010SBRT.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Median high\u2010risk clinical target volume (HR\u2010CTV) D98% was 78.7\u2009Gy EQD2\n 10<\/jats:sub>\n , demonstrating adequate target coverage. Early imaging showed one complete response, one local progression and one combined local and metastatic progression. Acute toxicities were predominantly Grade 1, with one case of Grade 3 pelvic pain and no Grade 4 events.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n MRg\u2010SBRT boost was feasible and well tolerated, achieving reasonable dose escalation with acceptable toxicity, representing a potential alternative for patients' ineligible for brachytherapy.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n MARGARITA Protocol, NCT05937958<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/1754-9485.70185","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T14:36:00Z","timestamp":1789223760000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["MRI<\/scp>\n \u2010Guided\n SBRT<\/scp>\n Boost for Patients With Locally Advanced Cervical Cancer Who Are Unsuitable for Standard of Care Image\u2010Guided Brachytherapy"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2574-1098","authenticated-orcid":false,"given":"L.","family":"Edwards","sequence":"first","affiliation":[{"name":"GenesisCare Murdoch Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Tan","sequence":"additional","affiliation":[{"name":"GenesisCare Murdoch Perth WA Australia"},{"name":"Fiona Stanley Hospital Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Rahim","sequence":"additional","affiliation":[{"name":"GenesisCare Murdoch Perth WA Australia"},{"name":"Fiona Stanley Hospital Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Leong","sequence":"additional","affiliation":[{"name":"GenesisCare Murdoch Perth WA Australia"},{"name":"Fiona Stanley Hospital Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Carrillo\u2010Serrano","sequence":"additional","affiliation":[{"name":"GenesisCare Murdoch Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Liang","sequence":"additional","affiliation":[{"name":"GenesisCare Murdoch Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7023-7976","authenticated-orcid":false,"given":"H. L.","family":"Byrne","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health The University of Sydney Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"De Leon","sequence":"additional","affiliation":[{"name":"GenesisCare St Vincent Darlinghurst New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Sia","sequence":"additional","affiliation":[{"name":"GenesisCare Murdoch Perth WA Australia"},{"name":"Fiona Stanley Hospital Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8509-8250","authenticated-orcid":false,"given":"R.","family":"Chee","sequence":"additional","affiliation":[{"name":"GenesisCare Murdoch Perth WA Australia"},{"name":"Fiona Stanley Hospital Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,12]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Cancer Australia \u201cCervical Cancer in Australia Statistics \u201d(2022) https:\/\/www.canceraustralia.gov.au\/cancer\u2010types\/cervical\u2010cancer\/cervical\u2010cancer\u2010australia\u2010statistics#new\u2010cases."},{"key":"e_1_2_10_3_1","unstructured":"WHO \u201cCervical Cancer \u201d(2025) https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/cervical\u2010cancer."},{"issue":"143","key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.ygyno.2016.09.009","article-title":"Disparities in Standard of Care Treatment and Associated Survival Decrement in Patients With Locally Advanced Cervical Cancer","volume":"2","author":"Robin T. P.","year":"2016","journal-title":"Gynecologic Oncology"},{"issue":"5","key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.ijrobp.2014.07.017","article-title":"National Cancer Data Base Analysis of Radiation Therapy Consolidation Modality for Cervical Cancer: The Impact of New Technological Advancements","volume":"90","author":"Gill B. S.","year":"2014","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/1754-9485.13336","article-title":"Arly Experience With MR\u2010Guided Adaptive Radiotherapy Using a 1.5 T MR\u2010Linac: First 6 Months of Operation Using Adapt to Shape Workflow","volume":"66","author":"Leon J.","year":"2022","journal-title":"Journal of Medical Imaging and Radiation Oncology"},{"key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s13014-022-01981-z","article-title":"MR\u2010Guided SBRT Boost for Patients With Locally Advanced or Recurrent Gynecological Cancers Ineligible for Brachytherapy: Feasibility and Early Clinical Experience","volume":"17","author":"Hadi I.","year":"2022","journal-title":"Radiation Oncology"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.clon.2023.11.036","article-title":"Online Adaptive Magnetic Resonance\u2010Guided Radiation Therapy for Gynaecological Cancers: Preliminary Results of Feasibility and Outcome","volume":"36","author":"Ugurluer G.","year":"2024","journal-title":"Clinical Oncology"},{"issue":"10462","key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/S0140-6736(24)01438-7","article-title":"Induction Chemotherapy Followed by Standard Chemoradiotherapy Versus Standard Chemoradiotherapy Alone in Patients With Locally Advanced Cervical Cancer (GCIG INTERLACE): An International, Multicentre, Randomised Phase 3 Trial","volume":"404","author":"McCormack M.","year":"2024","journal-title":"Lancet"},{"key":"e_1_2_10_10_1","article-title":"EMBRACE\u2010II Protocol","volume":"22","author":"Tanderup K.","year":"2015","journal-title":"EMBRACE II Study Protocol V10"},{"key":"e_1_2_10_11_1","unstructured":"NCT05937958 \u201cMRLinac Boost for Gynecological Cancers if Brachytherapy is Not Feasible (MARGARITA) \u201dhttps:\/\/clinicaltrials.gov\/study\/NCT05937958."},{"key":"e_1_2_10_12_1","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.ijrobp.2007.10.066","article-title":"External Beam Boost for Cancer of the Cervix Uteri When Intracavitary Therapy Cannot Be Performed","volume":"71","author":"Baraclough L. 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I.","year":"2016","journal-title":"Cancer Investigation"}],"container-title":["Journal of Medical Imaging and Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1754-9485.70185","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1754-9485.70185","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1754-9485.70185","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T14:36:46Z","timestamp":1789223806000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1754-9485.70185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,12]]},"references-count":14,"alternative-id":["10.1111\/1754-9485.70185"],"URL":"https:\/\/doi.org\/10.1111\/1754-9485.70185","archive":["Portico"],"relation":{},"ISSN":["1754-9477","1754-9485"],"issn-type":[{"value":"1754-9477","type":"print"},{"value":"1754-9485","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,12]]},"assertion":[{"value":"2026-04-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1754-9485.70185"}}