{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T11:49:28Z","timestamp":1791373768103,"version":"4.3.1"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Stereotactic body radiotherapy has become an established treatment option for localised prostate cancer. However, real\u2010world evidence from routine clinical practice remains limited, particularly in cohorts that include older patients. We therefore report long\u2010term outcomes and treatment\u2010related adverse events after a uniform linear accelerator\u2013based stereotactic body radiotherapy regimen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed consecutive patients with localised prostate adenocarcinoma treated between May 2016 and June 2020 with definitive stereotactic body radiotherapy of 36.25\u2009Gy in five fractions delivered every other day. Risk stratification followed National Comprehensive Cancer Network criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 232 patients were included. The median age was 73\u2009years (range, 52\u201388), and the median follow\u2010up was 84.5\u2009months (range, 3.6\u2013113.8). Overall survival at 3, 5, and 7\u2009years was 98.2%, 95.1%, and 93.3%, respectively. Biochemical recurrence\u2010free survival at 3, 5, and 7\u2009years was 95.9%, 90.2%, and 87.8%, respectively. In patients with higher\u2010risk disease, biochemical recurrence\u2010free survival at 5\u2009years was 90.9% in the high\u2010risk group and 74.2% in the very high\u2010risk group. No Grade 3 acute gastrointestinal or genitourinary events occurred. Late Grade 3 genitourinary adverse events occurred in 5 patients (2.2%) and late Grade 3 gastrointestinal adverse events in 3 patients (1.3%); no Grade 4 or 5 treatment\u2010related adverse events were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this single\u2010institution real\u2010world cohort, linear accelerator\u2013based stereotactic body radiotherapy was associated with long\u2010term disease control and a limited incidence of severe late adverse events. These findings support implementation of five\u2010fraction prostate stereotactic body radiotherapy in routine practice with appropriate patient counselling and long\u2010term surveillance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1754-9485.70202","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T10:49:57Z","timestamp":1791370197000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Linear Accelerator\u2013Based Stereotactic Body Radiotherapy of 36.25\u2009Gy in Five Fractions for Localised Prostate Cancer: A Retrospective Single\u2010Institution Cohort Study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4393-1828","authenticated-orcid":false,"given":"Atsuto","family":"Katano","sequence":"first","affiliation":[{"name":"Department of Radiology The University of Tokyo Hospital  Tokyo 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