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Molluscan shells undergo ectopic biomineralization to form the exoskeleton and biocalcified \u201cpearl\u201d involved in invading defence. Notably, exo\u2010\/endoskeletons have a common ancestral origin, but their regulation and body growth are largely unknown. This study employed the pearl oyster, <jats:italic>Pinctada fucata marntensii<\/jats:italic>, a widely used experimental model for biomineralization in invertebrates, to perform whole\u2010genome resequencing of 878 individuals from wild and breeding populations. This study characterized the genetic architecture of biomineralization\u2010controlled growth and ectopic biomineralization. The insulin\u2010like growth factor (IGF) endocrine signal interacted with ancient single\u2010copy transcription factors to form the regulatory network. Moreover, the \u201ccross\u2010phylum\u201d regulation of key long noncoding RNA (lncRNA) in bivalves and mammals indicated the conserved genetic and epigenetic regulation in exo\u2010\/endoskeleton growth. Thyroid hormone signal and apoptosis regulation in pearl oysters affected ectopic biomineralization in pearl oyster. These findings provide insights into the mechanism underlying the evolution and regulation of biomineralization in exo\u2010\/endoskeleton animals and ectopic biomineralization.<\/jats:p>","DOI":"10.1111\/1755-0998.13743","type":"journal-article","created":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T14:15:28Z","timestamp":1669990528000},"page":"680-693","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Genome\u2010wide association study analysis to resolve the key regulatory mechanism of biomineralization in <i>Pinctada fucata martensii<\/i>"],"prefix":"10.1111","volume":"23","author":[{"given":"Zhe","family":"Zheng","sequence":"first","affiliation":[{"name":"Fisheries College Guangdong Ocean University  Zhanjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijuan","family":"Hao","sequence":"additional","affiliation":[{"name":"Development and Research Center for Biological Marine 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