{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T12:15:17Z","timestamp":1789215317258,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,7,18]],"date-time":"2013-07-18T00:00:00Z","timestamp":1374105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of this study was to investigate the effects of spironolactone on left ventricular (<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>) remodeling in patients with preserved <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> function following acute myocardial infarction (<jats:styled-content style=\"fixed-case\">AMI<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Successfully revascularized patients (n\u00a0=\u00a0186) with acute <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content> elevation <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">STEMI<\/jats:styled-content>) were included in the study. Patients were randomly divided into three groups, each of which was administered a different dose of spironolactone (12.5, 25\u00a0mg, or none). Echocardiography was performed within the first 3\u00a0days and at 6\u00a0months after <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>. Echocardiography control was performed on 160 patients at a 6\u2010month follow\u2010up. The median left ventricular ejection fraction (<jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content>) increased significantly in all groups, but no significant difference was observed between groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.13). At the end of the sixth month, the myocardial performance index (<jats:styled-content style=\"fixed-case\">MPI<\/jats:styled-content>) had improved in each of the three groups, but no significant difference was found between groups (F\u00a0=\u00a02.00, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.15). The mean <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> peak systolic velocities (S<jats:sub>m<\/jats:sub>) increased only in the control group during the follow\u2010up period, but there is no significant difference between groups (F\u00a0=\u00a01.79, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.18). The left ventricular end\u2010systolic volume index (<jats:styled-content style=\"fixed-case\">LVESVI<\/jats:styled-content>) and the left ventricular end\u2010diastolic volume index (<jats:styled-content style=\"fixed-case\">LVEDVI<\/jats:styled-content>) did not change significantly compared with the basal values between groups (F\u00a0=\u00a00.05, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.81 and F\u00a0=\u00a01.03, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.31, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In conclusion, spironolactone dosages of up to 25\u00a0mg do not augment optimal medical treatment for <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> remodeling in patients with preserved cardiac functions after <jats:styled-content style=\"fixed-case\">AMI<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1755-5922.12006","type":"journal-article","created":{"date-parts":[[2012,9,11]],"date-time":"2012-09-11T11:58:30Z","timestamp":1347364710000},"page":"224-229","source":"Crossref","is-referenced-by-count":13,"title":["Does Spironolactone Have a Dose\u2010Dependent Effect on Left Ventricular Remodeling in Patients with Preserved Left Ventricular Function After an Acute Myocardial Infarction?"],"prefix":"10.1111","volume":"31","author":[{"given":"Mehmet Akif","family":"Vatankulu","sequence":"first","affiliation":[{"name":"Cardiology Department Faculty of Medicine Bezmialem Vakif University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Bacaksiz","sequence":"additional","affiliation":[{"name":"Cardiology Department Faculty of Medicine Bezmialem Vakif University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osman","family":"Sonmez","sequence":"additional","affiliation":[{"name":"Cardiology Department Faculty of Medicine Bezmialem Vakif University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf","family":"Alihanoglu","sequence":"additional","affiliation":[{"name":"Cardiology Department Faculty of Medicine Pamukkale University Denizli Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih","family":"Koc","sequence":"additional","affiliation":[{"name":"Cardiology Department Faculty of Medicine Gaziosmanpasa University Tokat Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenan","family":"Demir","sequence":"additional","affiliation":[{"name":"Cardiology Department Faculty of Medicine Selcuk University Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enes 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