{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:23:08Z","timestamp":1765545788558},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,4,18]],"date-time":"2013-04-18T00:00:00Z","timestamp":1366243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The pathophysiology of cardiac syndrome <jats:styled-content style=\"fixed-case\">X<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">CSX<\/jats:styled-content>) is still unclear, but most patients with <jats:styled-content style=\"fixed-case\">CSX<\/jats:styled-content> have endothelial dysfunction. It has been shown that adropin uniquely effects the regulation of endothelial function. The purpose of the study was to evaluate the role of adropin in <jats:styled-content style=\"fixed-case\">CSX<\/jats:styled-content>. Eighty\u2010six consecutive cardiac syndrome <jats:styled-content style=\"fixed-case\">X<\/jats:styled-content>\u2010diagnosed patients and 86 age\u2010sex matched healthy subjects were enrolled into the study. Serum adropin levels, nitrite\/nitrate levels were measured in each subject. The adropin levels were significantly lower in patients with CSX than healthy subjects (1.7\u00a0\u00b1\u00a00.8\u00a0ng\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> and 3.4\u00a0\u00b1\u00a01.8\u00a0ng\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>, respectively; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). The BMI values of patients with CSX were significantly higher than control subjects (28.1\u00a0\u00b1\u00a02.4\u00a0kg\/m<jats:sup>2<\/jats:sup> and 26.0\u00a0\u00b1\u00a03.7\u00a0kg\/m<jats:sup>2<\/jats:sup>, respectively; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Plasma nitrite\/nitrate levels were lower in patients with CSX than control subjects (15.9\u00a0\u00b1\u00a01.6<jats:bold>\u00a0<\/jats:bold>\u03bcmol\/L vs. 25.4\u00a0\u00b1\u00a02.8\u00a0\u03bcmol\/L, respectively; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), and they have a significantly positive correlation with plasma adropin levels (r\u00a0=\u00a00.463, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). In the multiple linear regression analysis, nitrite\/nitrate levels, BMI, and adropin were found to be independent risk factors for <jats:styled-content style=\"fixed-case\">CSX<\/jats:styled-content>. A <jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content> curve is used to identify the ability of adropin levels to predict the cardiac syndrome X. The area under the <jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content> curve was 0.854 for adropin levels (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0001). The sensitivity and specificity values of adropin levels were 90.7 and 70.9%, respectively (cut\u2010off value 2.73). In conclusion, lower serum adropin levels were associated with CSX. Adropin is an independent risk factor for CSX.<\/jats:p>","DOI":"10.1111\/1755-5922.12025","type":"journal-article","created":{"date-parts":[[2013,1,29]],"date-time":"2013-01-29T12:08:04Z","timestamp":1359461284000},"page":"174-178","source":"Crossref","is-referenced-by-count":70,"title":["Deficiency of a New Protein Associated with Cardiac Syndrome X; Called Adropin"],"prefix":"10.1111","volume":"31","author":[{"given":"Ahmet","family":"Celik","sequence":"first","affiliation":[{"name":"Department of Cardiology Elazig Education and Research Hospital Elazig Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Balin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Elazig Education and Research Hospital Elazig Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Ali","family":"Kobat","sequence":"additional","affiliation":[{"name":"Department of Cardiology Elazig Education and Research Hospital Elazig 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