{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T23:51:08Z","timestamp":1778284268025,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T00:00:00Z","timestamp":1385510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cilostazol, a selective phosphodiesterase three inhibitor, has been proposed to have beneficial effects in the prevention of atherosclerosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We aimed to investigate the effects of cilostazol on carotid intima\u2010media thickening (<jats:styled-content style=\"fixed-case\">IMT<\/jats:styled-content>) and total plaque area (<jats:styled-content style=\"fixed-case\">TPA<\/jats:styled-content>) in patients with retinal vascular occlusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 63 consecutive vascular occlusive retinopathy patients with carotid atherosclerosis were enrolled. We examined changes in the carotid <jats:styled-content style=\"fixed-case\">IMT<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">TPA<\/jats:styled-content> and visual acuity\/macular thickness before and after 1\u2010year treatment with cilostazol (200\u00a0mg\/day).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean <jats:styled-content style=\"fixed-case\">IMT<\/jats:styled-content> of both common carotid arteries (<jats:styled-content style=\"fixed-case\">CCA<\/jats:styled-content>s) and internal carotid arteries (<jats:styled-content style=\"fixed-case\">ICA<\/jats:styled-content>s) were significantly reduced after cilostazol treatment. There was no significant difference in the <jats:styled-content style=\"fixed-case\">TPA<\/jats:styled-content> of both <jats:styled-content style=\"fixed-case\">CCA<\/jats:styled-content>s before and after the treatment (before; 0.61\u00a0\u00b1\u00a00.94 vs. after; 0.45\u00a0\u00b1\u00a00.79\u00a0cm<jats:sup>2<\/jats:sup>, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.291); however, significant plaque regression (before; 0.14\u00a0\u00b1\u00a00.15 vs. after; 0.25\u00a0\u00b1\u00a00.14 cm<jats:sup>2<\/jats:sup>, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.004) was observed in selected patients (n\u00a0=\u00a030) with a <jats:styled-content style=\"fixed-case\">TPA<\/jats:styled-content> &lt;0.5\u00a0cm<jats:sup>2<\/jats:sup>. The improvement in macular thickness was significantly associated with an improvement in carotid <jats:styled-content style=\"fixed-case\">IMT<\/jats:styled-content> (r\u00a0=\u00a00.42, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001) and <jats:styled-content style=\"fixed-case\">TPA<\/jats:styled-content> (r\u00a0=\u00a00.23, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cilostazol potently inhibited the progression of carotid <jats:styled-content style=\"fixed-case\">IMT<\/jats:styled-content> and may play a role in the early carotid plaque regression in patients with retinal vascular occlusion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1755-5922.12042","type":"journal-article","created":{"date-parts":[[2013,8,12]],"date-time":"2013-08-12T15:13:00Z","timestamp":1376320380000},"source":"Crossref","is-referenced-by-count":6,"title":["Impact of Cilostazol on the Progression of Carotid Atherosclerosis in Patients 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