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These antibiotics prolong the phase 3 of the action potential and cause early after depolarization and dispersion of repolarization that precipitate TdP. The potency of these drugs, as potassium channel blockers, is very low, and differences between them are minimal. Underlying impaired cardiac repolarization is a prerequisite for arrhythmia induction. Impaired cardiac repolarization can be congenital in the young or acquired in adults. The most important risk factors are a prolonged baseline<jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>c interval or a combination with class<jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>antiarrhythmic drugs. Modifiable risk factors, including hypokalemia, hypomagnesemia, drug interactions, and bradycardia, should be corrected. In the absence of a major risk factor, the incidence of TdP is very low. The use of these drugs in the appropriate settings of infection should not be altered because of the rare risk of TdP, except among cases with high\u2010risk factors.<\/jats:p>","DOI":"10.1111\/1755-5922.12054","type":"journal-article","created":{"date-parts":[[2013,11,7]],"date-time":"2013-11-07T07:12:47Z","timestamp":1383808367000},"page":"19-25","source":"Crossref","is-referenced-by-count":84,"title":["Antibiotic\u2010induced Cardiac Arrhythmias"],"prefix":"10.1111","volume":"32","author":[{"given":"Elsayed","family":"Abo\u2010Salem","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Diseases University of Cincinnati Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Fowler","sequence":"additional","affiliation":[{"name":"Department of Physiology Texas Tech University Health Sciences Center Lubbock TX 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