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Alongside statin therapy, which is maintained to be an effective method of <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content> prevention, there are alternative methods such as vitamin B substitution therapy with folic acid (<jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content>), and vitamins B<jats:sub>12<\/jats:sub> and B<jats:sub>6<\/jats:sub>. B\u2010vitamins may inhibit atherogenesis by decreasing the plasma level of homocysteine (Hcy)\u2014a suspected etiological factor for atherosclerosis\u2014and by other mechanisms, primarily through their antioxidant properties. Although Hcy\u2010lowering vitamin trials have failed to demonstrate beneficial effects of B\u2010vitamins in the prevention of <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>, a meta\u2010analysis and stratification of a number of large vitamin trials have suggested their effectiveness in cardiovascular prevention (<jats:styled-content style=\"fixed-case\">CVP<\/jats:styled-content>) in some aspects. Furthermore, interpretation of the results from these large vitamin trials has been troubled by statin\/aspirin therapy, which was applied along with the vitamin substitution, and <jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content> fortification, both of which obscured the separate effects of vitamins in <jats:styled-content style=\"fixed-case\">CVP<\/jats:styled-content>. Recent research results have accentuated a new approach to vitamin therapy for <jats:styled-content style=\"fixed-case\">CVP<\/jats:styled-content>. Studies undertaken with the aim of primary prevention have shown that vitamin B substitution may be effective in the primary prevention of <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content> and may also be an option in the secondary prevention of disease if statin therapy is accompanied by serious adverse effects. Further investigations are needed to determine the validity of vitamin substitution therapy before its introduction in the protocol of <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content> prevention.<\/jats:p>","DOI":"10.1111\/1755-5922.12064","type":"journal-article","created":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T13:31:45Z","timestamp":1393421505000},"page":"130-138","source":"Crossref","is-referenced-by-count":102,"title":["The Role of Homocysteine\u2010Lowering B\u2010Vitamins in the Primary Prevention of Cardiovascular Disease"],"prefix":"10.1111","volume":"32","author":[{"given":"Balazs","family":"Debreceni","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Medical Chemistry Medical School University of Pecs Pecs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laszlo","family":"Debreceni","sequence":"additional","affiliation":[{"name":"Heart Disease Research Foundation Brooklyn NY 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