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No previous study compared the effect of any fibrate on plasma levels of lipids and other cardiovascular risk factors in patients with different thyroid function status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included three age\u2010, weight\u2010 and lipid\u2010matched groups of women with mixed dyslipidemia in different thyroid function status: patients with untreated subclinical hypothyroidism (group 1, n\u00a0=\u00a018), women with treated hypothyroidism (group 2, n\u00a0=\u00a015), and subjects without thyroid disorders (group 3, n\u00a0=\u00a019). Plasma lipids, glucose homeostasis markers, as well as plasma levels of uric acid, high\u2010sensitivity C\u2010reactive protein (hs<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>), homocysteine, and fibrinogen were determined before and after 12\u00a0weeks of fenofibrate therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Despite similar plasma lipid levels, mixed dyslipidemic patients with untreated hypothyroidism had decreased insulin sensitivity, as well as higher circulating levels of uric acid, hs<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>, homocysteine, and fibrinogen in comparison with the other groups. The effect of fenofibrate on plasma lipids and, with the exception of homocysteine, on circulating levels of all investigated risk factors was stronger in patients from groups 2 and 3 than in patients from group 1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The obtained results indicate that the effect of fenofibrate on plasma lipids and circulating levels of cardiovascular risk factors is partially related to thyroid function. They also suggest that to improve the strength of fibrate action in dyslipidemic patients with subclinical hypothyroidism, they should be administered together with <jats:sc>l<\/jats:sc>\u2010thyroxine.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1755-5922.12095","type":"journal-article","created":{"date-parts":[[2014,10,7]],"date-time":"2014-10-07T11:25:33Z","timestamp":1412681133000},"page":"264-269","source":"Crossref","is-referenced-by-count":9,"title":["Different Effects of Fenofibrate on Metabolic and Cardiovascular Risk Factors in Mixed Dyslipidemic Women With Normal Thyroid Function and Subclinical Hypothyroidism"],"prefix":"10.1111","volume":"32","author":[{"given":"Robert","family":"Krysiak","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Clinical Pharmacology Medical University of Silesia Katowice 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