{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T23:21:22Z","timestamp":1789600882860,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T00:00:00Z","timestamp":1431388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"department of science and technology, India","award":["SR\/SO\/HS-049\/2010"],"award-info":[{"award-number":["SR\/SO\/HS-049\/2010"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      Cardiac hypertrophy and myocardial fibrosis significantly contribute to the pathogenesis of diabetic cardiomyopathy (\n                      <jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content>\n                      ). Altered expression of several genes and their regulation by micro\n                      <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                      s has been reported in hypertrophied failing hearts.\u00a0This study aims to examine the role of Cdc42, Pak1, and miR\u201030c in the pathogenesis of cardiac hypertrophy in\n                      <jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content>\n                      was induced in Wistar rats by low\u2010dose streptozotocin\u2010high\u2010fat diet for 12\u00a0weeks. Cardiac expression of Cdc42, Pak1 and miR\u201030c, and hypertrophy markers (\n                      <jats:styled-content style=\"fixed-case\">ANP<\/jats:styled-content>\n                      and\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">MHC<\/jats:styled-content>\n                      ) was studied in\n                      <jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content>\n                      vs control rats and in high\u2010glucose (\n                      <jats:styled-content style=\"fixed-case\">HG<\/jats:styled-content>\n                      )\u2010treated H9c2 cardiomyocytes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Diabetic rats showed cardiomyocyte hypertrophy, increased heart\u2010to\u2010body weight ratio, and an increased expression of\n                      <jats:styled-content style=\"fixed-case\">ANP<\/jats:styled-content>\n                      and\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">MHC<\/jats:styled-content>\n                      . Cardiac expression of Cdc42 and Pak1 genes was increased in diabetic hearts and in\n                      <jats:styled-content style=\"fixed-case\">HG<\/jats:styled-content>\n                      \u2010treated cardiomyocytes. miR\u201030c was identified to target Cdc42 and Pak1 genes, and cardiac miR\u201030c expression was found to be decreased in\n                      <jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content>\n                      rats, patients with\n                      <jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content>\n                      , and in\n                      <jats:styled-content style=\"fixed-case\">HG<\/jats:styled-content>\n                      \u2010treated cardiomyocytes. miR\u201030c overexpression decreased Cdc42 and Pak1 genes and attenuated\n                      <jats:styled-content style=\"fixed-case\">HG<\/jats:styled-content>\n                      \u2010induced cardiomyocyte hypertrophy, whereas miR\u201030c inhibition increased Cdc42\u00a0and Pak1 gene expression and myocyte hypertrophy in\n                      <jats:styled-content style=\"fixed-case\">HG<\/jats:styled-content>\n                      \u2010treated cardiomyocytes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Downregulation of miR\u201030c mediates prohypertrophic effects of hyperglycemia in\n                      <jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content>\n                      by upregulation of Cdc42 and Pak1 genes.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1755-5922.12113","type":"journal-article","created":{"date-parts":[[2015,3,17]],"date-time":"2015-03-17T05:45:56Z","timestamp":1426571156000},"page":"89-97","source":"Crossref","is-referenced-by-count":63,"title":["miR\u201030c Mediates Upregulation of Cdc42 and Pak1 in Diabetic Cardiomyopathy"],"prefix":"10.1111","volume":"33","author":[{"given":"Satish K.","family":"Raut","sequence":"first","affiliation":[{"name":"Department of Experimental Medicine and Biotechnology Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akhilesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine and Biotechnology Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurinder B.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine and Biotechnology Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uma","family":"Nahar","sequence":"additional","affiliation":[{"name":"Department of Histopathology Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vibhuti","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Histopathology Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anupam","family":"Mittal","sequence":"additional","affiliation":[{"name":"Department of Cardiology Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajni","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine and Biotechnology Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhu","family":"Khullar","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine and Biotechnology Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2013.01.037"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-012-9313-3"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.12.3461"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.915701"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00506.2013"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M009316200"},{"key":"e_1_2_9_8_1","unstructured":"MaoK.P21\u2010activated kinase 1 regulates pathological and physiological cardiac hypertrophy. 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