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It is considered a minimally invasive and safe procedure which, as shown by initial experimental and clinical trials, is able not only to reduce blood pressure but also to modify its risk factors by modulation of autonomic nervous system. Recently published results of a randomized Symplicity <jats:styled-content style=\"fixed-case\">HTN<\/jats:styled-content>\u20103 trial, which failed to demonstrate <jats:styled-content style=\"fixed-case\">RDN<\/jats:styled-content>\u2010induced reduction of blood pressure at six months, decreased the initial enthusiasm regarding <jats:styled-content style=\"fixed-case\">RDN<\/jats:styled-content> and raised a question about real efficacy of this procedure. Nevertheless, still there are some other conditions characterized by increased sympathetic tone such as heart failure, atrial fibrillation, or ventricular arrhythmias that may benefit from <jats:styled-content style=\"fixed-case\">RDN<\/jats:styled-content>. Furthermore, novel therapeutical approach toward <jats:styled-content style=\"fixed-case\">RDN<\/jats:styled-content> using adapted electrophysiological or new specially designed electrodes may improve effectiveness of <jats:styled-content style=\"fixed-case\">RDN<\/jats:styled-content> procedure.<\/jats:p>","DOI":"10.1111\/1755-5922.12116","type":"journal-article","created":{"date-parts":[[2015,3,18]],"date-time":"2015-03-18T16:18:07Z","timestamp":1426695487000},"page":"141-144","source":"Crossref","is-referenced-by-count":2,"title":["Renal Denervation\u2014Hypes and Hopes"],"prefix":"10.1111","volume":"33","author":[{"given":"Joanna","family":"Lewek","sequence":"first","affiliation":[{"name":"Department of Electrocardiology Sterling Regional Heart Disease Center Medical University Lodz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Kaczmarek","sequence":"additional","affiliation":[{"name":"Department of Electrocardiology Sterling Regional 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