{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T07:44:59Z","timestamp":1696405499752},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,7,7]],"date-time":"2015-07-07T00:00:00Z","timestamp":1436227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Early intervention is certainly a preferred strategy over conservative management in patients with post\u2010infarction angina (<jats:styled-content style=\"fixed-case\">PIA<\/jats:styled-content>). But at times, it may not be feasible to intervene, especially if patient refuses for intervention. In a pilot study, we analyzed whether the addition of eptifibatide to intensified antianginal therapy would be of added benefit, in patients with <jats:styled-content style=\"fixed-case\">PIA<\/jats:styled-content> not willing to undergo intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 461 patients with <jats:styled-content style=\"fixed-case\">PIA<\/jats:styled-content> who refused intervention were randomized in a 1:1 manner to receive either eptifibatide along with intensification of antianginal therapy (group A; n\u00a0=\u00a0229) or intensified antianginal therapy alone (group B; n\u00a0=\u00a0232). The primary endpoints were composite of all\u2010cause death and nonfatal myocardial infarction at 30\u00a0days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Primary composite endpoint did not differ between the two groups (16.2% vs. 18.9% in group A and group B, odds ratio [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>], 0.82; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.5\u20131.30; <jats:italic>P<\/jats:italic>\u2010value\u00a0=\u00a00.43). Significant earlier relief of angina (complete relief of angina within 12\u00a0h: 76% of patients in group A vs. 40.5% in group B; <jats:italic>P<\/jats:italic>\u2010value &lt;0.0001) was achieved in group A compared to group B. Although on Bleeding Academic Research Consortium (<jats:styled-content style=\"fixed-case\">BARC<\/jats:styled-content>) scale, type 1 and 2 bleeding was higher in group A (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 3.18; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.76\u20135.74; <jats:italic>P<\/jats:italic>\u2010value\u00a0=\u00a00.0001), the more serious (composite of type 3 and 5) bleeds did not show any difference (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 1.73; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.7\u20134.08; <jats:italic>P<\/jats:italic>\u2010value\u00a0=\u00a00.21).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients with <jats:styled-content style=\"fixed-case\">PIA<\/jats:styled-content> who refused intervention, eptifibatide infusion resulted in earlier relief of angina albeit at the cost of increased non\u2013life\u2010threatening bleeding. Further, this effect was achieved in significantly higher number of patients receiving eptifibatide infusion when compared to patients not receiving it. Primary composite endpoints, however, did not differ in two groups, but being a pilot study, this needs to be confirmed by larger study of adequate sample size.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1755-5922.12123","type":"journal-article","created":{"date-parts":[[2015,4,18]],"date-time":"2015-04-18T07:13:42Z","timestamp":1429341222000},"page":"155-160","source":"Crossref","is-referenced-by-count":0,"title":["Eptifibatide in Post\u2010infarction Angina Patients who refused Intervention: Ajmer Postmyocardial Infarction Angina Eptifibatide Research (<scp>AJMER<\/scp>) Study: A Pilot Study"],"prefix":"10.1111","volume":"33","author":[{"given":"Rajendra","family":"Gokhroo","sequence":"first","affiliation":[{"name":"Department of Cardiology Institute of Cardiology JLN Medical College &amp; Associated Group of Hospitals Ajmer India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamal","family":"Kishor","sequence":"additional","affiliation":[{"name":"Department of Cardiology Institute of Cardiology JLN Medical College &amp; Associated Group of Hospitals Ajmer India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhanwar","family":"Ranwa","sequence":"additional","affiliation":[{"name":"Department of Cardiology Institute of Cardiology JLN Medical College &amp; Associated Group of Hospitals Ajmer India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devendra Singh","family":"Bisht","sequence":"additional","affiliation":[{"name":"Department of Cardiology Institute of Cardiology JLN Medical College &amp; Associated Group of Hospitals Ajmer India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sajal","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Cardiology Institute of Cardiology JLN Medical College &amp; Associated Group of Hospitals Ajmer India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avinash","family":"Anantharaj","sequence":"additional","affiliation":[{"name":"Department of Cardiology Institute of Cardiology JLN Medical College &amp; Associated Group of Hospitals Ajmer India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/7.suppl_C.3"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198111053051901"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8651(18)30509-5"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.12.1195"},{"key":"e_1_2_9_6_1","first-page":"1279","article-title":"Unstable angina: report from a Canadian expert roundtable","volume":"12","author":"Cairns J","year":"1996","journal-title":"Can J Cardiol"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.80.2.410"},{"key":"e_1_2_9_8_1","first-page":"202","article-title":"The clinical use of the GPIIb\/IIIa inhibitors eptifibatide and tirofiban in the treatment of acute coronary syndromes of the \u201cnon\u2010ST elevation\u201d type","volume":"1","author":"Galli M","year":"2000","journal-title":"Ital Heart J Suppl"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2005.03.029"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199808133390704"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.5.1488"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.11.019"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.009449"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.4.809"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2006.05.001"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7156.468"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7172.1572"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.10763"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01124.x"}],"container-title":["Cardiovascular Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1755-5922.12123","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1755-5922.12123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T12:30:25Z","timestamp":1696336225000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1755-5922.12123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,7]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1111\/1755-5922.12123"],"URL":"https:\/\/doi.org\/10.1111\/1755-5922.12123","archive":["Portico"],"relation":{},"ISSN":["1755-5914","1755-5922"],"issn-type":[{"value":"1755-5914","type":"print"},{"value":"1755-5922","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,7]]}}}