{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:30:30Z","timestamp":1761863430726,"version":"3.37.3"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,7,7]],"date-time":"2015-07-07T00:00:00Z","timestamp":1436227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>For decades, unfractionated heparin (<jats:styled-content style=\"fixed-case\">UFH<\/jats:styled-content>) has been widely used in catheterization laboratories for anticoagulation for percutaneous coronary intervention (<jats:styled-content style=\"fixed-case\">PCI<\/jats:styled-content>). The direct thrombin inhibitors, bivalirudin, has emerged as an alternative to <jats:styled-content style=\"fixed-case\">UFH<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">PCI<\/jats:styled-content> procedures, due to its lower bleeding risk. More recently, randomized trials and meta\u2010analyses questioned the efficacy of bivalirudin, and demonstrated that bivalirudin might be associated with a higher incidence of ischemic events and in particular stent thrombosis. In this review, we discuss the pharmacology of bivalirudin along with the clinical evidence comparing bivalirudin versus <jats:styled-content style=\"fixed-case\">UFH<\/jats:styled-content> in patients undergoing <jats:styled-content style=\"fixed-case\">PCI<\/jats:styled-content> for various indications.<\/jats:p>","DOI":"10.1111\/1755-5922.12124","type":"journal-article","created":{"date-parts":[[2015,4,16]],"date-time":"2015-04-16T11:41:24Z","timestamp":1429184484000},"page":"227-235","source":"Crossref","is-referenced-by-count":6,"title":["Bivalirudin in Percutaneous Coronary Intervention, is it the Anticoagulant of Choice?"],"prefix":"10.1111","volume":"33","author":[{"given":"Ahmed","family":"Mahmoud","sequence":"first","affiliation":[{"name":"Department of Medicine University of Florida Gainesville FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwan","family":"Saad","sequence":"additional","affiliation":[{"name":"Department of Medicine Seton Hall University School of Health and Medical Sciences Trinitas Regional Medical Center Elizabeth NJ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9853-7591","authenticated-orcid":false,"given":"Akram Y.","family":"Elgendy","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Florida Gainesville FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Abuzaid","sequence":"additional","affiliation":[{"name":"Department of Medicine Creighton University Omaha NE USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Islam Y.","family":"Elgendy","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Florida Gainesville FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.11.019"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.09.017"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.07.013"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.109.884478"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013404"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.14.1759"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031859"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.818617"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.108.847582.108.847582"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062437"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0708191"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.7.853"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61216-2"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60924-7"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00364a025"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-3466.2005.tb00177.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1A197"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2002.124522"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2002.122173"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.87.5.1622"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199509213331204"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2001.119374"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0807986"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2012.05.008"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60450-4"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.298.21.2497"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1109596"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802944"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq330"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2014.10.015"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60764-2"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1311096"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu214"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.10.029"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp186"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2014.09.025"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu182"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.2323"},{"key":"e_1_2_10_40_1","unstructured":"ValgimigliM.Minimizing Adverse Haemorrhagic Events by TRansradial Access Site and Systemic Implementation of angioX (MATRIX). Presented at the American College of Cardiology conference 15 San Diego California USA March 16 2015."},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g6419"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2014.10.003"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJY14M08_01"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(04)01601-8"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2011-301323"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.110.957290"}],"container-title":["Cardiovascular Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1755-5922.12124","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1755-5922.12124","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T12:31:05Z","timestamp":1696336265000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1755-5922.12124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,7]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1111\/1755-5922.12124"],"URL":"https:\/\/doi.org\/10.1111\/1755-5922.12124","archive":["Portico"],"relation":{},"ISSN":["1755-5914","1755-5922"],"issn-type":[{"type":"print","value":"1755-5914"},{"type":"electronic","value":"1755-5922"}],"subject":[],"published":{"date-parts":[[2015,7,7]]}}}