{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T04:19:22Z","timestamp":1782101962483,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,7,7]],"date-time":"2015-07-07T00:00:00Z","timestamp":1436227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate the regional cerebral blood flow, cognitive function, and parameters of 24\u2010h arterial blood pressure monitoring in patients with metabolic syndrome before and after combination antihypertensive therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study involved 54 patients with metabolic syndrome (MetS) investigated by brain single\u2010photon emission computed tomography, 24\u2010h blood pressure monitoring (<jats:styled-content style=\"fixed-case\">ABPM<\/jats:styled-content>), and comprehensive neuropsychological testing before and after 24\u00a0weeks of combination antihypertensive therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with metabolic syndrome had significantly poorer regional cerebral blood flow compared with control group: by 7% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003) in right anterior parietal cortex, by 6% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.028) in left anterior parietal cortex, by 8% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.007) in right superior frontal lobe, and by 10% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.00002) and 7% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.006) in right and left temporal brain regions, correspondingly. The results of neuropsychological testing showed 11% decrease in mentation (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002), and 19% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.011) and 20% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.009) decrease in immediate verbal and visual memory in patients with MetS as compared with control group. Relationships between the indices of <jats:styled-content style=\"fixed-case\">ABPM<\/jats:styled-content>, cerebral perfusion, and cognitive function were found. Data showed an improvement of regional cerebral blood flow, <jats:styled-content style=\"fixed-case\">ABPM<\/jats:styled-content> parameters, and indicators of cognitive functions after 6\u00a0months of antihypertensive therapy in patients with MetS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study showed the presence of diffuse disturbances in cerebral perfusion is associated with cognitive disorders in patients with metabolic syndrome. Combination antihypertensive treatment exerts beneficial effects on the 24\u2010h blood pressure profile, increases cerebral blood flow, and improves cognitive function in patients with MetS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1755-5922.12136","type":"journal-article","created":{"date-parts":[[2015,5,19]],"date-time":"2015-05-19T11:01:57Z","timestamp":1432033317000},"page":"209-215","source":"Crossref","is-referenced-by-count":13,"title":["Influence of Antihypertensive Therapy on Cerebral Perfusion in Patients with Metabolic Syndrome: Relationship with Cognitive Function and 24\u2010h Arterial Blood Pressure Monitoring"],"prefix":"10.1111","volume":"33","author":[{"given":"Nataliya Y.","family":"Efimova","sequence":"first","affiliation":[{"name":"Federal State Budgetary Scientific Institution Research Institute for Cardiology Tomsk Russia"},{"name":"National Research Tomsk Polytechnic University Tomsk Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir 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