{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:35:46Z","timestamp":1761896146633},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,1,8]],"date-time":"2016-01-08T00:00:00Z","timestamp":1452211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81200153"],"award-info":[{"award-number":["81200153"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>The purpose of this study was to clarify the effect of mini\u2010tyrosyl\u2010tRNA synthetase\/mini\u2010tryptophanyl\u2010tRNA synthetase (mini\u2010TyrRS\/mini\u2010TrpRS) in ischemic angiogenesis in rhesus monkeys with acute myocardial infarction (AMI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A 27\u2010gauge needle was incorporated percutaneously into the left ventricular myocardium of rhesus monkeys with AMI. All monkeys were randomized to receive adenoviral vector mini\u2010TyrRS\/mini\u2010TrpRS, which was administered as five injections into the infarcted myocardium, or saline or ad\u2010null (control groups). The injections were guided by EnSite NavX left ventricular electroanatomical mapping. Mini\u2010TyrRS\/mini\u2010TrpRS proteins were detected by Western blot and immunoprecipitation analyses. Microvessel density (MVD) per section was measured using immunostaining with a CD34 monoclonal antibody. Proliferating cardiomyocytes were identified through histological and immunohistochemical analyses. Myocardial perfusion and cardiac function were estimated by G\u2010SPECT. Infarction size was also measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Western blot analyses showed that compared to the normal zone, the expression level of mini\u2010TyrRS\/mini\u2010TrpRS was significantly different in the infarction zone. G\u2010SPECT analysis indicated that the mini\u2010TyrRS group had better cardiac function and myocardial perfusion after the injection of ad\u2010mini\u2010TyrRS than before, while mini\u2010TrpRS injection had a totally opposite effect. After mini\u2010TyrRS was administered, there was less of an infarction zone and more proliferating cardiomyocytes and capillaries in the mini\u2010TyrRS group compared to both of the control groups, and the ad\u2010mini\u2010TrpRS group had a totally opposite effect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results indicated that angiogenesis could be either stimulated by mini\u2010TyrRS or inhibited by mini\u2010TrpRS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1755-5922.12161","type":"journal-article","created":{"date-parts":[[2015,9,24]],"date-time":"2015-09-24T05:34:57Z","timestamp":1443072897000},"page":"4-12","source":"Crossref","is-referenced-by-count":8,"title":["Effect of Mini\u2010Tyrosyl\u2010tRNA Synthetase\/Mini\u2010Tryptophanyl\u2010tRNA Synthetase on Angiogenesis in Rhesus Monkeys after Acute Myocardial Infarction"],"prefix":"10.1111","volume":"34","author":[{"given":"Rui","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Cardiology West China Hospital School of Clinic Medicine Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology West China Hospital School of Clinic Medicine Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gui\u2010ying","family":"You","sequence":"additional","affiliation":[{"name":"Department of Cardiology West China Hospital School of Clinic Medicine Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong\u2010zheng","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Nephrology West China Hospital School of Clinic Medicine Sichuan University Chengdu 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