{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T20:20:36Z","timestamp":1793046036347,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,3,3]],"date-time":"2016-03-03T00:00:00Z","timestamp":1456963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"departmental resources"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Nonadherence to secondary preventative medications after stroke is common and is associated with poor outcomes. Numerous strategies exist to promote adherence. We performed a systematic review and meta\u2010analysis to describe the efficacy of strategies to improve adherence to stroke secondary prevention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We created a sensitive search strategy and searched multiple electronic databases (MEDLINE, EMBASE, CINAHL, PsycINFO, CENTRAL, and Web of Knowledge) for studies of interventions that aimed to enhance adherence to secondary preventative medication after stroke. We assessed quality of included studies using the Cochrane tool for assessing risk of bias. We performed narrative review and performed meta\u2010analysis where data allowed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 12,237 titles, we included seventeen studies in our review. Eleven studies were considered to have high risk of bias, 3 with unclear risk, and 3 of low risk. Meta\u2010analysis of available data suggested that these interventions improved adherence to individual medication classes (blood pressure\u2010lowering drugs \u2013 OR, 2.21; 95% CI (1.63, 2.98), [<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001], lipid\u2010lowering drugs \u2013 OR, 2.11; 95% CI (1.00, 4.46), [<jats:italic>P<\/jats:italic>\u00a0=\u00a00.049], and antithrombotic drugs \u2013 OR, 2.32; 95% CI (1.18, 4.56, [<jats:italic>P<\/jats:italic>\u00a0=\u00a00.014]) but did not improve adherence to an overall secondary preventative medication regimen (OR, 1.96; 95% CI (0.50, 7.67), [<jats:italic>P<\/jats:italic>\u00a0=\u00a00.332]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Interventions can lead to improvement in adherence to secondary preventative medication after stroke. However, existing data is limited as several interventions, duration of follow\u2010up, and various definitions were used. These findings need to be interpreted with caution.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1755-5922.12176","type":"journal-article","created":{"date-parts":[[2016,1,28]],"date-time":"2016-01-28T14:46:39Z","timestamp":1453992399000},"page":"85-93","source":"Crossref","is-referenced-by-count":13,"title":["Multimodal Interventions to Enhance Adherence to Secondary Preventive Medication after Stroke: A Systematic Review and Meta\u2010Analyses"],"prefix":"10.1111","volume":"34","author":[{"given":"Sukainah","family":"Al AlShaikh","sequence":"first","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences University of Glasgow Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry","family":"Quinn","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences University of Glasgow Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Dunn","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences University of Glasgow Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Walters","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences University of Glasgow Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse","family":"Dawson","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences University of Glasgow Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,3]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68734-5"},{"key":"e_1_2_12_3_1","first-page":"Cd001342","article-title":"Vitamin K antagonists versus antiplatelet therapy after transient ischaemic attack or minor ischaemic stroke of presumed arterial origin","volume":"9","author":"De Schryver EL","year":"2012","journal-title":"Cochrane Database Sys Rev"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.324.7329.71"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d2083"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06178-5"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000092488.40085.15"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000126208.14181.DD"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15690-0"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70058-4"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000106480.76217.6F"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000017877.62543.14"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-4-200908180-00135"},{"key":"e_1_2_12_14_1","unstructured":"HigginsJ GreenS editors.Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. 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