{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T15:31:43Z","timestamp":1740151903934,"version":"3.37.3"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,5,18]],"date-time":"2016-05-18T00:00:00Z","timestamp":1463529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Capital Medical Development Scientific Research Fund","award":["2009-2074"],"award-info":[{"award-number":["2009-2074"]}]},{"name":"Capital Health Development Scientific Research Fund","award":["2014-1-4016"],"award-info":[{"award-number":["2014-1-4016"]}]},{"DOI":"10.13039\/501100009331","name":"Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support","doi-asserted-by":"crossref","award":["XMLM201406"],"award-info":[{"award-number":["XMLM201406"]}],"id":[{"id":"10.13039\/501100009331","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The dual antiplatelet therapy (<jats:styled-content style=\"fixed-case\">DAPT<\/jats:styled-content>) and the response of clopidogrel were two pivotal issues in drug\u2010eluting stent (<jats:styled-content style=\"fixed-case\">DES<\/jats:styled-content>) era.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To analyze the combined impacts of <jats:styled-content style=\"fixed-case\">DAPT<\/jats:styled-content> and the response to clopidogrel to evaluate their long\u2010term effect on patients undergoing <jats:styled-content style=\"fixed-case\">DES<\/jats:styled-content> implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Platelet aggregation was serially measured by light transmission aggregometry in all eligible patients during the course of treatment with <jats:styled-content style=\"fixed-case\">DAPT<\/jats:styled-content>, and the mean platelet aggregation degree of each participant was calculated. Based on the duration of <jats:styled-content style=\"fixed-case\">DAPT<\/jats:styled-content> and the mean platelet aggregation degree, all the enrolled patients were then divided into four groups. The primary endpoint was a composite of major adverse cardiovascular events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We analyzed 1245 suitable patients in this study. They were divided into four groups: Group A (12\u2010month <jats:styled-content style=\"fixed-case\">DAPT<\/jats:styled-content> &amp; low platelet aggregation degree) with 233 subjects, Group B (12\u2010month <jats:styled-content style=\"fixed-case\">DAPT<\/jats:styled-content> &amp; high platelet aggregation degree) with 260 subjects, Group C (&gt;12\u2010month <jats:styled-content style=\"fixed-case\">DAPT<\/jats:styled-content> &amp; low platelet aggregation degree) with 374 subjects, and Group D (&gt;12\u2010month <jats:styled-content style=\"fixed-case\">DAPT<\/jats:styled-content> &amp; high platelet aggregation degree) with 378 subjects. Group C was associated with a decreased incidence of primary endpoints [<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 0.512, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> (0.27\u20130.97); <jats:italic>P<\/jats:italic>\u00a0=\u00a00.040]. The Cox proportional hazard model was further analyzed with Groups A and B combined as the reference category [<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> for Group C vs. Group A, 0.84, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> (0.33\u20132.15); <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.719; <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> for Group C vs. Group B, 0.45, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> (0.21\u20130.98); <jats:italic>P<\/jats:italic>\u00a0=\u00a00.043]. Their respective multivariate Cox proportional hazard regressions confirmed these trends.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The mean platelet aggregation degree is of importance in long\u2010term use of <jats:styled-content style=\"fixed-case\">DAPT<\/jats:styled-content>; extension of <jats:styled-content style=\"fixed-case\">DAPT<\/jats:styled-content> beyond 1 year should be implemented cautiously in patients implanted with <jats:styled-content style=\"fixed-case\">DES<\/jats:styled-content>s.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1755-5922.12177","type":"journal-article","created":{"date-parts":[[2016,1,30]],"date-time":"2016-01-30T14:03:45Z","timestamp":1454162625000},"page":"127-137","source":"Crossref","is-referenced-by-count":1,"title":["The Importance of the Mean Platelet Aggregation Degree in Long\u2010term Dual Antiplatelet Therapy Following Drug\u2010Eluting Stent Implantation"],"prefix":"10.1111","volume":"34","author":[{"given":"Quan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Disease Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuejun","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Disease Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianpeng","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Disease Beijing 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