{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:52:32Z","timestamp":1789095152980,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,5,18]],"date-time":"2016-05-18T00:00:00Z","timestamp":1463529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The objective of this study was to establish the benefit of bisoprolol up\u2010titration toward recommended dosage targets, versus lower\u2010dose maintenance, in heart failure (<jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>) patients with systolic dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Korean <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content> patients received bisoprolol 1.25\u00a0mg\/day, incrementally up\u2010titrated toward 10\u00a0mg\/day in the absence of contraindications. After 26\u00a0weeks' treatment, patients were grouped as low\u2010dose (&lt;3.75\u00a0mg\/day) or high\u2010dose (\u22653.75\u00a0mg\/day). Primary endpoint was change in serum N\u2010terminal probrain natriuretic peptide (<jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content>\u2010pro<jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content>). Other markers of <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content> were also evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>159 of 180 enrolled patients were evaluable. After 16\u00a0weeks' follow\u2010up, there were 52 and 107 patients in the low\u2010 and high\u2010dose groups respectively. Mean bisoprolol dosage was 5.4\u00a0mg\/day; 24% of patients achieved target (10\u00a0mg\/day). Mean log<jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content>\u2010pro<jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content> significantly decreased in both groups, with no significant difference in the magnitude of change between groups. Mean heart rate (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>) and blood pressure decreased significantly in both groups, but only <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> showed a significantly greater change in high\u2010dose versus low\u2010dose patients. In both groups, mean left ventricular (<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>) end\u2010systolic and end\u2010diastolic dimensions were significantly decreased and mean <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> ejection fraction was significantly improved. Mean 6\u2010min walk test distances improved in both groups (significant in low\u2010dose\u00a0patients only). Functional class improvement was observed in both low\u2010 and high\u2010dose patients. No patients were rehospitalized due to aggravated <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content> patients with systolic dysfunction, any bisoprolol dose is beneficial, but an attempt to up\u2010titrate toward guideline\u2010recommended dosages offers additional benefit in terms of restoration of <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> systolic function and remodeling.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1755-5922.12185","type":"journal-article","created":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T15:13:22Z","timestamp":1458659602000},"page":"172-179","source":"Crossref","is-referenced-by-count":3,"title":["Beneficial Effect on Surrogate Markers of Heart Failure with Bisoprolol Up\u2010Titration to Recommended Targets in Korean Patients with Heart Failure and Left Ventricular Systolic Dysfunction"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0678-223X","authenticated-orcid":false,"given":"Seong Woo","family":"Han","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Dongtan Sacred Heart Hospital College of Medicine Hallym University Hwasung Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suk\u2010Won","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Dongtan Sacred Heart Hospital College of Medicine Hallym University Hwasung Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu\u2010Hyung","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Dongtan Sacred Heart Hospital College of Medicine Hallym University Hwasung Republic of 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