{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T04:44:31Z","timestamp":1715575471789},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,9,28]],"date-time":"2016-09-28T00:00:00Z","timestamp":1475020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81201093","81571680"],"award-info":[{"award-number":["81201093","81571680"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Effects of ischemic postconditioning (<jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content>ostC) and adenosine triphosphate (<jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content>)\u2010mediated pharmacologic postconditioning (<jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PP<\/jats:styled-content>ostC) on cardiac function were evaluated by speckle tracking imaging (<jats:styled-content style=\"fixed-case\">STI<\/jats:styled-content>)\u2010based echocardiography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>A myocardial I\/R model was induced in rabbits by reversible ligation of the left ventricular branch of coronary artery. Rabbits were randomized into three groups: ischemia and reperfusion (<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>) (no further intervention), <jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content>ostC, and <jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PP<\/jats:styled-content>ostC groups. Cardiac function was evaluated by conventional and <jats:styled-content style=\"fixed-case\">STI<\/jats:styled-content>\u2010based echocardiography. Myocardial necrosis, apoptosis, and myocardial <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>s of apoptosis\u2010related proteins (Bcl\u20102 and Bax) were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Speckle tracking imaging (<jats:styled-content style=\"fixed-case\">STI<\/jats:styled-content>)\u2010based echocardiography revealed that <jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content>ostC and <jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PP<\/jats:styled-content>ostC were associated with better preserved global and regional cardiac function, as indicated by significantly increased <jats:styled-content style=\"fixed-case\">GLS<\/jats:styled-content>rsys, <jats:styled-content style=\"fixed-case\">GLS<\/jats:styled-content>rd, <jats:styled-content style=\"fixed-case\">GLS<\/jats:styled-content>sys, SrLsys, SrLd, and <jats:styled-content style=\"fixed-case\">SL<\/jats:styled-content>sys in both groups (all <jats:italic>P<\/jats:italic>&lt;.5). Subsequent pathologic studies indicate that the percentage of necrotic myocardium and permillage of apoptotic cells were significantly lower in the <jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content>ostC and <jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PP<\/jats:styled-content>ostC groups than in the <jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> group (all <jats:italic>P<\/jats:italic>&lt;.05). Moreover, both <jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content>ostC and <jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PP<\/jats:styled-content>ostC were associated with increased Bcl\u20102 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> levels and reduced Bax <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content>ostC and <jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PP<\/jats:styled-content>ostC may exert cardioprotective functions by better preservation of cardiac function during the I\/R process and at least partly via attenuation of myocardial apoptosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1755-5922.12205","type":"journal-article","created":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T19:02:44Z","timestamp":1466622164000},"page":"343-351","source":"Crossref","is-referenced-by-count":5,"title":["Adenosine triphosphate postconditioning is associated with better preserved global and regional cardiac function during myocardial ischemia and reperfusion: a speckle tracking imaging\u2010based echocardiologic study"],"prefix":"10.1111","volume":"34","author":[{"given":"Min","family":"Ren","sequence":"first","affiliation":[{"name":"Department of Ultrasound Second Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Second Affiliated Hospital of Harbin Medical University  Harbin 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