{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T23:34:20Z","timestamp":1784244860001,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,9,28]],"date-time":"2016-09-28T00:00:00Z","timestamp":1475020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We aimed to compare the effects of fixed\u2010dose combinations of ezetimibe plus rosuvastatin to rosuvastatin alone in patients with primary hypercholesterolemia, including a subgroup analysis of patients with diabetes mellitus (DM) or metabolic syndrome (MetS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This multicenter eight\u2010week randomized double\u2010blind phase III study evaluated the safety and efficacy of fixed\u2010dose combinations of ezetimibe 10\u00a0mg plus rosuvastatin, compared with rosuvastatin alone in patients with primary hypercholesterolemia. Four hundred and seven patients with primary hypercholesterolemia who required lipid\u2010lowering treatment according to the ATP III guideline were randomized to one of the following six treatments for 8\u00a0weeks: fixed\u2010dose combinations with ezetimibe 10\u00a0mg daily plus rosuvastatin (5, 10, or 20\u00a0mg daily) or rosuvastatin alone (5, 10, or 20\u00a0mg daily).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fixed\u2010dose combination of ezetimibe plus rosuvastatin significantly reduced LDL cholesterol, total cholesterol, and triglyceride levels compared with rosuvastatin alone. Depending on the rosuvastatin dose, these fixed\u2010dose combinations of ezetimibe plus rosuvastatin provided LDL cholesterol, total cholesterol, and triglyceride reductions of 56%\u201363%, 37%\u201343%, and 19%\u201324%, respectively. Moreover, the effect of combination treatment on cholesterol levels was more pronounced in patients with DM or MetS than in non\u2010DM or non\u2010MetS patients, respectively, whereas the effect of rosuvastatin alone did not differ between DM vs non\u2010DM or MetS vs non\u2010MetS patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fixed\u2010dose combinations of ezetimibe and rosuvastatin provided significantly superior efficacy to rosuvastatin alone in lowering LDL cholesterol, total cholesterol, and triglyceride levels. Moreover, the reduction rate was greater in patients with DM or MetS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1755-5922.12213","type":"journal-article","created":{"date-parts":[[2016,8,10]],"date-time":"2016-08-10T08:53:23Z","timestamp":1470819203000},"page":"371-382","source":"Crossref","is-referenced-by-count":60,"title":["Effect of fixed\u2010dose combinations of ezetimibe plus rosuvastatin in patients with primary hypercholesterolemia: MRS\u2010ROZE (Multicenter Randomized Study of ROsuvastatin and eZEtimibe)"],"prefix":"10.1111","volume":"34","author":[{"given":"Kyung\u2010Jin","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Seoul National University Hospital Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang\u2010Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine 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