{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T23:59:01Z","timestamp":1774310341031,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,11,12]],"date-time":"2016-11-12T00:00:00Z","timestamp":1478908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2016,12]]},"abstract":"Summary<\/jats:title>Objectives<\/jats:title>Longitudinal data are limited regarding outcomes and costs beyond 1\u00a0year after acute myocardial infarction (MI<\/jats:styled-content>) among elderly (\u226565\u00a0years old) US<\/jats:styled-content> patients. This study examined long\u2010term outcomes and healthcare costs among elderly MI<\/jats:styled-content> survivors.<\/jats:p><\/jats:sec>Methods<\/jats:title>Retrospective analysis of 2002\u20132009 Medicare healthcare claims (5% random sample). Patients were \u226565\u00a0years old and survived \u22651\u00a0year without recurrent MI<\/jats:styled-content> after MI<\/jats:styled-content> hospitalization. Mortality, incidence of hospitalizations for stroke, major bleeding, MI<\/jats:styled-content>, a composite endpoint (death, MI<\/jats:styled-content>, or stroke), and nonpharmacy healthcare costs were determined.<\/jats:p><\/jats:sec>Results<\/jats:title>Eligible patients included 16\u00a0244 STEMI<\/jats:styled-content>, 34\u00a0576 NSTEMI<\/jats:styled-content>, and 3109 unspecified MI<\/jats:styled-content>. NSTEMI<\/jats:styled-content> and unspecified MI<\/jats:styled-content> patients had significantly higher prevalence of comorbidities than STEMI<\/jats:styled-content> patients, except for hypertension and dyslipidemia. MI<\/jats:styled-content> incidence declined 36% over the follow\u2010up (3.82\/100 person\u2010years [PY<\/jats:styled-content>] to 2.45\/100 PY<\/jats:styled-content>). Mortality, stroke, and bleeding decreased until the third year of follow\u2010up and then increased. NSTEMI<\/jats:styled-content> and unspecified MI<\/jats:styled-content> patients had a significantly higher incidence of death, MI<\/jats:styled-content>, the composite, and bleeding than STEMI<\/jats:styled-content> patients throughout follow\u2010up. All\u2010cause inpatient costs during follow\u2010up were 2.6\u2010 and 1.9\u2010fold higher than baseline for STEMI<\/jats:styled-content> and NSTEMI<\/jats:styled-content>, respectively; cardiovascular\u2010related inpatient costs were 3.5\u2010 and 2.2\u2010fold higher, respectively.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Risks of mortality and cardiovascular events remain high in a Medicare population surviving >1\u00a0year after a MI<\/jats:styled-content>. Continuing healthcare costs are doubled over pre\u2010MI<\/jats:styled-content> levels up to 5\u00a0years after an MI<\/jats:styled-content>. Secondary prevention measures beyond the acute post\u2010MI<\/jats:styled-content> period may be indicated to reduce risk and cost in this chronic disease phase.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1755-5922.12222","type":"journal-article","created":{"date-parts":[[2016,8,26]],"date-time":"2016-08-26T13:44:00Z","timestamp":1472219040000},"page":"450-459","source":"Crossref","is-referenced-by-count":18,"title":["Clinical and economic outcomes among elderly myocardial infarction survivors in the United States"],"prefix":"10.1111","volume":"34","author":[{"given":"Erru","family":"Yang","sequence":"first","affiliation":[{"name":"Evidera Waltham MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Stokes","sequence":"additional","affiliation":[{"name":"Evidera Waltham MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saga","family":"Johansson","sequence":"additional","affiliation":[{"name":"AstraZeneca R&D Molndal Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl","family":"Mellstr\u00f6m","sequence":"additional","affiliation":[{"name":"AstraZeneca R&D Molndal Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Magnuson","sequence":"additional","affiliation":[{"name":"Saint Luke's Mid America Heart Institute University of Missouri\u2010Kansas City School of Medicine Kansas City MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Saint Luke's Mid America Heart Institute University of Missouri\u2010Kansas City School of Medicine Kansas City MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip","family":"Hunt","sequence":"additional","affiliation":[{"name":"Evidera Waltham MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-009-0381-8"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.10.824"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31828478ac"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.181940"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1500857"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1409312"},{"key":"e_1_2_10_8_1","unstructured":"Bureau of Labor Statistics.Consumer Price Index for All Urban Consumers: U.S. City Average January 2012 B.o.L.S. 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