{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:00:36Z","timestamp":1767164436708,"version":"build-2238731810"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,3,13]],"date-time":"2017-03-13T00:00:00Z","timestamp":1489363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Science Fund Committee of Guang Dong Province, China","award":["2008A030201011"],"award-info":[{"award-number":["2008A030201011"]}]},{"name":"Junhong Company, Dongguan, China"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Our previous study indicates that hydrochlorothiazide inhibits transforming growth factor (TGF)\u2010\u03b2\/Smad signaling pathway, improves cardiac function and reduces fibrosis. We determined whether these effects were common among the diuretics and whether angiotensin II receptor type 1 (AT1) signaling pathway played a role in these effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Heart failure was produced by ligating the left anterior descending coronary artery in adult male Sprague Dawley rats. Two weeks after the ligation, 70 rats were randomly divided into five groups: sham\u2010operated group, control group, valsartan group (80\u00a0mg\/kg\/d), hydrochlorothiazide group (12.5\u00a0mg\/kg\/d) and furosemide group (20\u00a0mg\/kg\/d). In addition, neonatal rat ventricular fibroblasts were treated with angiotensin II.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After eight\u2010week drug treatment, hydrochlorothiazide group and valsartan group but not furosemide group had improved cardiac function (ejection fraction was 49.4\u00b12.1%, 49.5\u00b11.8% and 39.9\u00b11.9%, respectively, compared with 40.1\u00b12.2% in control group), reduced cardiac interstitial fibrosis and collagen volume fraction (9.7\u00b11.2%, 10.0\u00b11.3% and 14.1\u00b10.8%, respectively, compared with 15.9\u00b11.1% in control group), and decreased expression of AT1, TGF\u2010\u03b2 and Smad2 in the cardiac tissues. In addition, hydrochlorothiazide reduced plasma angiotensin II and aldosterone levels. Furthermore, hydrochlorothiazide inhibited angiotensin II\u2010induced TGF\u2010\u03b21 and Smad2 protein expression in the neonatal rat ventricular fibroblasts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study indicates that the cardiac function and remodeling improvement after ischemic heart failure may not be common among the diuretics. Hydrochlorothiazide may reduce the left ventricular wall stress and angiotensin II signaling pathway to provide these beneficial effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1755-5922.12246","type":"journal-article","created":{"date-parts":[[2016,12,31]],"date-time":"2016-12-31T05:46:35Z","timestamp":1483163195000},"source":"Crossref","is-referenced-by-count":9,"title":["Hydrochlorothiazide modulates ischemic heart failure\u2010induced cardiac remodeling via inhibiting angiotensin II type 1 receptor pathway in rats"],"prefix":"10.1111","volume":"35","author":[{"given":"Jinghong","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Cardiology, First Affiliated Hospital Zhong\u2010Shan University  Guangzhou China"},{"name":"Department of Geriatrics Huizhou Municipal Central Hospital  Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuanlan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department 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