{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T07:17:11Z","timestamp":1779261431201,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,3,13]],"date-time":"2017-03-13T00:00:00Z","timestamp":1489363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2017,4]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Percutaneous coronary intervention (PCI<\/jats:styled-content>) with early\u2010generation drug\u2010eluting stent (eDES<\/jats:styled-content>) implantation for ostial right coronary artery (RCA<\/jats:styled-content>) lesions is challenging because of the frequent need for repeat revascularization. We compared midterm clinical outcomes following eDES<\/jats:styled-content> or new\u2010generation DES<\/jats:styled-content> (nDES<\/jats:styled-content>) implantation for ostial RCA<\/jats:styled-content> lesions.<\/jats:p><\/jats:sec>Methods<\/jats:title>The study included 150 patients with ostial RCA<\/jats:styled-content> lesions, 76 treated with eDES<\/jats:styled-content> and 74 with nDES<\/jats:styled-content> between January 2005 and September 2013. Study endpoints were major adverse cardiac events (MACE<\/jats:styled-content>s), specifically all\u2010cause death, target lesion revascularization (TLR<\/jats:styled-content>), or myocardial infarction within 2\u00a0years after PCI.<\/jats:p><\/jats:sec>Results<\/jats:title>Patient characteristics between the groups were similar. The MACE<\/jats:styled-content> rate was significantly lower in patients treated with nDES<\/jats:styled-content> compared with those treated with eDES<\/jats:styled-content>, mainly driven by the lower rates of TLR<\/jats:styled-content> in the nDES<\/jats:styled-content> group. Cox regression analysis identified severe chronic kidney disease (CKD<\/jats:styled-content>) and the use of nDES<\/jats:styled-content> as the independent predictors of MACE.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The implantation of nDES<\/jats:styled-content> for ostial RCA<\/jats:styled-content> lesions significantly reduced the MACE<\/jats:styled-content> rate compared with early\u2010generation DES<\/jats:styled-content>, mainly driven by a reduction in the TLR<\/jats:styled-content> rate. However, nDES<\/jats:styled-content> implantations for ostial RCA<\/jats:styled-content> lesions may still be challenging in patients with severe CKD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1755-5922.12247","type":"journal-article","created":{"date-parts":[[2016,12,31]],"date-time":"2016-12-31T10:52:39Z","timestamp":1483181559000},"source":"Crossref","is-referenced-by-count":11,"title":["Comparison of early\u2010 and new\u2010generation drug\u2010eluting stent implantations for ostial right coronary artery lesions"],"prefix":"10.1111","volume":"35","author":[{"given":"Yusuke","family":"Watanabe","sequence":"first","affiliation":[{"name":"Interventional Cardiology Unit New Tokyo Hospital Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kensuke","family":"Takagi","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit New Tokyo Hospital Chiba 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