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In addition, the effect of sEH<\/jats:styled-content> inhibitors on endothelial function was evaluated in vitro and ex vivo using isolated rat thoracic aorta.<\/jats:p><\/jats:sec>Results<\/jats:title>Ischemia\u2010reperfusion (IR<\/jats:styled-content>) increased the myocardial damage in hearts from normal rats. IR<\/jats:styled-content>\u2010induced myocardial damage was augmented in hearts isolated from hypertensive and diabetic rats. Myocardial damage as evident from increase in the activities of lactate dehydrogenase (LDH<\/jats:styled-content>) and creatine kinase\u2010MB<\/jats:styled-content> (CK<\/jats:styled-content>\u2010MB<\/jats:styled-content>) in heart perfusate was associated with significant decrease in the heart rate and developed tension, and increase in the resting tension in isolated heart. Both sEH<\/jats:styled-content> inhibitors protected the heart in normal, hypertensive, and diabetic rats subjected to IR<\/jats:styled-content> injury. The sEH<\/jats:styled-content> inhibitor t<\/jats:italic>\u2010TUCB<\/jats:styled-content> relaxed phenylephrine precontracted aorta from normal rats. Relaxant effect of acetylcholine (AC<\/jats:styled-content>h) was reduced in aortas from diabetic and hypertensive rats compared to normal rats. Pretreatment of sEH<\/jats:styled-content> inhibitors to diabetic and hypertensive rats increased relaxant effect of AC<\/jats:styled-content>h on aortas isolated from these rats.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Prophylactic treatment with sEH<\/jats:styled-content> inhibitors decreased myocardial damage due to IR<\/jats:styled-content>, hypertension and diabetes, and decreased endothelial dysfunction created by diabetes and hypertension. Therefore, inhibitors of sEH<\/jats:styled-content> are useful probes to study cardiovascular pathology, and inhibition of the sEH<\/jats:styled-content> is a potential approach in the management of IR<\/jats:styled-content>\u2010induced cardiac damage and endothelial dysfunction\u2010related cardiovascular disorders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1755-5922.12259","type":"journal-article","created":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T06:53:01Z","timestamp":1489560781000},"source":"Crossref","is-referenced-by-count":22,"title":["Inhibitors of soluble epoxide hydrolase minimize ischemia\u2010reperfusion\u2010induced cardiac damage in normal, hypertensive, and diabetic rats"],"prefix":"10.1111","volume":"35","author":[{"given":"Oliul","family":"Islam","sequence":"first","affiliation":[{"name":"Department of Pharmacology Al\u2010Ameen College of Pharmacy Bangalore Karnataka 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