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Cardiac stem cells (<jats:styled-content style=\"fixed-case\">CSC<\/jats:styled-content>s) provided a new option to treat acute <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>. This study was to investigate the effects of <jats:styled-content style=\"fixed-case\">CSC<\/jats:styled-content>s on structural and functional alteration in acute <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Acute <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> was induced in 20 Sprague\u2010Dawley rats by ligation of the left anterior descending coronary artery. Two weeks after <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>, animals were randomized into <jats:styled-content style=\"fixed-case\">CSC<\/jats:styled-content>s or control group. <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> geometry and function were echocardiographically measured at baseline, 2, 4, and 6\u00a0weeks after <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>. After measuring hemodynamics at 6\u00a0weeks after <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>, hearts were harvested for tracing <jats:styled-content style=\"fixed-case\">CSC<\/jats:styled-content>s stained by <jats:styled-content style=\"fixed-case\">PKH<\/jats:styled-content>26 and testing expression of <jats:italic><jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>\u2010<\/jats:italic>\u03b1<jats:italic>\/<jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010<\/jats:italic>\u03b2<jats:italic>1<\/jats:italic> by <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two weeks after <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>, there were significant decreases in interventricular septal systolic and diastolic thickness (<jats:styled-content style=\"fixed-case\">IVST<\/jats:styled-content>s\/d), while increases in <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> systolic and diastolic dimension (<jats:styled-content style=\"fixed-case\">LVD<\/jats:styled-content>s\/d). Consequently, this contributed to decreases in ejection fraction (<jats:styled-content style=\"fixed-case\">EF<\/jats:styled-content>) and fractional shorting (<jats:styled-content style=\"fixed-case\">FS<\/jats:styled-content>). With the treatment of <jats:styled-content style=\"fixed-case\">CSC<\/jats:styled-content>s for 4\u00a0weeks, significant better ejection fraction (<jats:styled-content style=\"fixed-case\">EF<\/jats:styled-content>) and fractional shorting (<jats:styled-content style=\"fixed-case\">FS<\/jats:styled-content>) were achieved in <jats:styled-content style=\"fixed-case\">CSC<\/jats:styled-content>s group accompanied by the reduction in <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> systole and diastole dimension (<jats:styled-content style=\"fixed-case\">LVD<\/jats:styled-content>s\/d). Besides, a significant improvement in the maximal rate of <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> pressure development and decline (peak +<jats:styled-content style=\"fixed-case\">d<jats:italic>P<\/jats:italic><\/jats:styled-content>\/d<jats:italic>t<\/jats:italic> and \u2010<jats:styled-content style=\"fixed-case\">d<jats:italic>P<\/jats:italic><\/jats:styled-content>\/d<jats:italic>t<\/jats:italic>, respectively) was observed. Moreover, significantly higher <jats:italic><jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>\u2010<\/jats:italic>\u03b1 was expressed in <jats:styled-content style=\"fixed-case\">CSC<\/jats:styled-content>s group rather than <jats:italic><jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010<\/jats:italic>\u03b2<jats:italic>1<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CSC<\/jats:styled-content>s significantly prevented structural and functional deterioration after <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> with increasing expression of <jats:italic><jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>\u2010<\/jats:italic>\u03b1.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1755-5922.12313","type":"journal-article","created":{"date-parts":[[2017,11,24]],"date-time":"2017-11-24T06:26:49Z","timestamp":1511504809000},"source":"Crossref","is-referenced-by-count":3,"title":["The effect of allogeneic cardiac stem cells in left ventricular geometry and function in a rat model of myocardial infarction"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6241-2479","authenticated-orcid":false,"given":"Yinlun","family":"Weng","sequence":"first","affiliation":[{"name":"Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anmin","family":"Liu","sequence":"additional","affiliation":[{"name":"Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wangqing","family":"Cai","sequence":"additional","affiliation":[{"name":"Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangcheng","family":"Li","sequence":"additional","affiliation":[{"name":"Guangzhou Women and Children's Medical Center  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong","family":"Wang","sequence":"additional","affiliation":[{"name":"Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.81.4.1161"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)00845-X"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2009.12.044"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03401776"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/35070587"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/term.7"},{"key":"e_1_2_7_8_1","first-page":"1629","article-title":"[Isolation, in vitro culture and identification of cardiac stem cells from neonatal SD rats]","volume":"26","author":"Lu DF","year":"2006","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.655209"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318206d6e8"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-012-9367-6"},{"key":"e_1_2_7_12_1","unstructured":"Institute of Laboratory Animal Resources (U.S.).Committee on Care and Use of Laboratory Animals. 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