{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:16:52Z","timestamp":1753877812266,"version":"3.41.2"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T00:00:00Z","timestamp":1521936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470450","81470451"],"award-info":[{"award-number":["81470450","81470451"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"publisher","award":["20161404"],"award-info":[{"award-number":["20161404"]}],"id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","award":["HL\u201028429","HL\u201066256","HL\u201085370"],"award-info":[{"award-number":["HL\u201028429","HL\u201066256","HL\u201085370"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Sotalol and verapamil alone reduce reentry incidence during ventricular fibrillation (VF). We tested whether the combination of these two drugs had a synergistic effect on initiation, maintenance, and termination of VF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Six open\u2010chest pigs received intravenous sotalol (1.5\u00a0mg\/kg) followed by verapamil (0.136\u00a0mg\/kg). VF threshold (VFT) was determined by a burst pacing protocol. Two 20\u00a0seconds episodes of VF were recorded from a 21\u00a0\u00d7\u00a024 unipolar electrode plaque on the lateral posterior left ventricular epicardium before and after each drug. VF activation patterns were quantified. The duration of long duration VF (LDVF) maintenance was compared to our previously published data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sotalol alone and combined with verapamil significantly increased the VFT from 12.3\u00a0\u00b1\u00a04.1 to 20.3\u00a0\u00b1\u00a07.1 and 26.7\u00a0\u00b1\u00a08.6\u00a0mA compared with baseline (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). Sotalol decreased the number of wavefronts by 20%, VF activation rate by 17% and conduction velocity 11%, while the addition of verapamil neutralized these effects. Addition of verapamil to sotalol further decreased the fractionation incidence from 14% to 29% and multiplicity from 24% to 31% compared with baseline. The combination of the two drugs increased the VF cycle length, decreased synchronicity, increased regularity index and shortened the duration of LDVF maintenance compared with our previous data of verapamil alone or no drug. Synchronicity index was lower and regularity index was higher in animals in which VF spontaneously terminated earlier than 10\u00a0minutes than in animals in which VF terminated longer than 10\u00a0minutes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The combination of sotalol and verapamil increased VFT but accelerated LDVF termination.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1755-5922.12326","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T12:02:37Z","timestamp":1519732957000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of combination of sotalol and verapamil on initiation, maintenance, and termination of ventricular fibrillation in swine hearts"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7683-072X","authenticated-orcid":false,"given":"Qi","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Cardiology Shanghai Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liqun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shanghai Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek J.","family":"Dosdall","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine CARMA Center University of Utah  Salt Lake City UT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine CARMA Center University of Utah  Salt Lake City UT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack M.","family":"Rogers","sequence":"additional","affiliation":[{"name":"Cardiac Rhythm Management Laboratory Department of Biomedical Engineering University of Alabama at Birmingham  Birmingham AL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond E.","family":"Ideker","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Disease Department of Medicine University of Alabama at Birmingham  Birmingham AL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Disease Department of Medicine University of Alabama at Birmingham  Birmingham AL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,25]]},"reference":[{"volume-title":"Cardiac electrophysiology: from cell to 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