{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T07:21:18Z","timestamp":1777101678815,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,5,25]],"date-time":"2018-05-25T00:00:00Z","timestamp":1527206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Haemonetics"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>There is potential value in testing individual response to P2Y12 inhibitors to predict ischemic and bleeding risk in patients undergoing percutaneous coronary intervention. The aims of this study were: (1) to validate the ability of a novel point of care (POC) assay, thrombelastography (TEG) 6s, to detect changes in adenosine diphosphate (ADP)\u2010induced whole blood clotting in volunteers and patients given clopidogrel using TEG 5000 as a reference and (2) to compare a novel, rapid parameter, area under the curve at 15\u00a0minutes (AUC15), with the traditional maximum clot amplitude (MA) in TEG 6s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 25 participants were included in whom ADP\u2010induced clotting was measured at 4 time points: (1) 12 healthy volunteers given 600\u00a0mg of clopidogrel; (2) 12 patients with ACS given 600\u00a0mg of clopidogrel; (3) 1 healthy volunteer given 600\u00a0mg of clopidogrel on 5 separate occasions. All samples were tested using conventional TEG 5000 and the new POC TEG 6S, and a new parameter called AUC15 was compared with MA in TEG 6s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>(1) TEG 5000 and TEG 6s both detected changes in ADP\u2010induced platelet activation. Bland\u2010Altman analysis demonstrated a good level of agreement between them. (2) For TEG 6S, correlation between MA and the novel AUC15 was strong for both thrombin and ADP channels (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.867, <jats:italic>R<\/jats:italic>\u00a0=\u00a0.936, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), and the AUC15 result was available on average 13.3\u00a0minutes earlier.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Thrombelastography 6s is a rapid, easy to use and accurate test of ADP\u2010induced clotting using TEG 5000 as a reference. A novel parameter, AUC15, is a viable, time\u2010saving option for this test and has potential value in personalized P2Y12 inhibitor therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1755-5922.12433","type":"journal-article","created":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T07:00:14Z","timestamp":1524466814000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Detection of individual responses to clopidogrel: Validation of a novel, rapid analysis using thrombelastography 6s"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5252-0479","authenticated-orcid":false,"given":"Bartosz","family":"Olechowski","sequence":"first","affiliation":[{"name":"Coronary Research Group University Hospital Southampton NHS Foundation Trust  Southampton UK"},{"name":"Faculty of Medicine University of Southampton  Southampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard T.","family":"Dalton","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Southampton  Southampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikram","family":"Khanna","sequence":"additional","affiliation":[{"name":"Coronary Research Group University Hospital Southampton NHS Foundation Trust  Southampton UK"},{"name":"Faculty of Medicine University of Southampton  Southampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Ashby","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Southampton  Southampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Vavyla","sequence":"additional","affiliation":[{"name":"Coronary Research Group University Hospital Southampton NHS Foundation Trust  Southampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Mariathas","sequence":"additional","affiliation":[{"name":"Coronary Research Group University Hospital Southampton NHS Foundation Trust  Southampton UK"},{"name":"Faculty of Medicine University of Southampton  Southampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Harris","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Southampton  Southampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoe","family":"Nicholas","sequence":"additional","affiliation":[{"name":"Coronary Research Group University Hospital Southampton NHS Foundation Trust  Southampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Mahmoudi","sequence":"additional","affiliation":[{"name":"Coronary Research Group University Hospital Southampton NHS Foundation Trust  Southampton UK"},{"name":"Faculty of Medicine University of Southampton  Southampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick","family":"Curzen","sequence":"additional","affiliation":[{"name":"Coronary Research Group University Hospital Southampton NHS Foundation Trust  Southampton UK"},{"name":"Faculty of Medicine University of Southampton  Southampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000072771.11429.83"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.09.067"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.812636"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.07.041"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn046"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.06.038"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706482"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0904327"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12907"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2096181"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.290"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.02.026"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1209979"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH13-10-0856"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/09537104.2014.1001832"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537100600935259"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lab.2004.01.011"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.05.090"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199902000-00016"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-198509000-00008"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-014-0518-9"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000155290.86795.12"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.111.967208"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/09537104.2016.1153617"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2016.1237626"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-17-00408"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2017.1392498"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537100701329162"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3109\/09537104.2010.543201"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-017-1477-1"},{"key":"e_1_2_8_32_1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1051\/ject\/201749026","article-title":"The TEG(R)6s on shaky ground? A novel assessment of the TEG(R)6s performance under a challenging condition","volume":"49","author":"Gill M","year":"2017","journal-title":"J Extra Corpor Technol"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2016-0088-OA"}],"container-title":["Cardiovascular Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1755-5922.12433","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1755-5922.12433","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T10:58:43Z","timestamp":1694948323000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1755-5922.12433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,25]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1111\/1755-5922.12433"],"URL":"https:\/\/doi.org\/10.1111\/1755-5922.12433","archive":["Portico"],"relation":{},"ISSN":["1755-5914","1755-5922"],"issn-type":[{"value":"1755-5914","type":"print"},{"value":"1755-5922","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,25]]},"assertion":[{"value":"2018-01-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12433"}}