{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T06:40:05Z","timestamp":1777272005735,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T00:00:00Z","timestamp":1530144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81441088"],"award-info":[{"award-number":["81441088"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Median nerve stimulation (<jats:styled-content style=\"fixed-case\">MNS<\/jats:styled-content>) is a novel neuromodulation approach for treatment of ventricular arrhythmia, but little is known about its chronic effects. The aim of this study was to investigate the effects of chronic <jats:styled-content style=\"fixed-case\">MNS<\/jats:styled-content> on ventricular arrhythmia and ventricular dysfunction postmyocardial infarction (<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Two weeks after <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>, 12 rabbits were randomly divided into control and <jats:styled-content style=\"fixed-case\">MNS<\/jats:styled-content> groups, and chronic <jats:styled-content style=\"fixed-case\">MNS<\/jats:styled-content> was performed in <jats:styled-content style=\"fixed-case\">MNS<\/jats:styled-content> group for 2\u00a0weeks. Ventricular function and arrhythmias; sympathetic innervation and activity; and interleukin\u20101 \u03b2 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101 \u03b2) and norepinephrine (<jats:styled-content style=\"fixed-case\">NE<\/jats:styled-content>) levels were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both the total number of premature ventricular complex and episodes of ventricular tachycardia were lower in <jats:styled-content style=\"fixed-case\">MNS<\/jats:styled-content> group than in control group (20\u00a0560\u00a0\u00b1\u00a010\u00a0314 beats vs 70\u00a0079\u00a0\u00b1\u00a037\u00a0184 beats, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.021, and 115\u00a0\u00b1\u00a063 episodes vs 307\u00a0\u00b1\u00a0164 episodes, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.034, respectively). Compared with control group, <jats:styled-content style=\"fixed-case\">MNS<\/jats:styled-content> decreased the cardiac sympathetic nerve density and level of circulating <jats:styled-content style=\"fixed-case\">NE<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">MNS<\/jats:styled-content> group (1798.42\u00a0\u00b1\u00a0644.07\u00a0\u03bcm<jats:sup>2<\/jats:sup>\/mm<jats:sup>2<\/jats:sup> vs 1003.79\u00a0\u00b1\u00a0453.00\u00a0\u03bcm<jats:sup>2<\/jats:sup>\/mm<jats:sup>2<\/jats:sup><jats:sub>,<\/jats:sub> <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.041, and 20.86\u00a0\u00b1\u00a04.54\u00a0pg\/mL vs 11.07\u00a0\u00b1\u00a01.43\u00a0pg\/mL, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.002, respectively). <jats:styled-content style=\"fixed-case\">MNS<\/jats:styled-content> also improved the left ventricular ejection fraction (59.07\u00a0\u00b1\u00a01.91% vs 49.77\u00a0\u00b1\u00a03.47%, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.003) and inhibited the level of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101 \u03b2 in serum (69.19\u00a0\u00b1\u00a04.71\u00a0pg\/mL vs 85.93\u00a0\u00b1\u00a012.80\u00a0pg\/mL, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.013).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Chronic <jats:styled-content style=\"fixed-case\">MNS<\/jats:styled-content> appears to protect against ventricular arrhythmia and improves ventricular function post\u2010<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>, which may be mediated by suppressing cardiac sympathetic activity and anti\u2010inflammatory effects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1755-5922.12437","type":"journal-article","created":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T14:31:05Z","timestamp":1527172265000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Chronic median nerve modulation reduces ventricular arrhythmia and improves ventricular function in a postmyocardial infarction rabbit model"],"prefix":"10.1111","volume":"36","author":[{"given":"Zhengqin","family":"Zhai","sequence":"first","affiliation":[{"name":"The Cardiac Arrhythmia Center State Key Laboratory of Cardiovascular Disease National Clinical Research Center of Cardiovascular Diseases National Center for Cardiovascular Diseases Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Zhao","sequence":"additional","affiliation":[{"name":"The Cardiac Arrhythmia Center State Key Laboratory of Cardiovascular Disease National Clinical Research Center of Cardiovascular Diseases National Center for Cardiovascular Diseases Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6647-2412","authenticated-orcid":false,"given":"Min","family":"Tang","sequence":"additional","affiliation":[{"name":"The Cardiac Arrhythmia Center State Key Laboratory of Cardiovascular Disease National Clinical Research Center of Cardiovascular Diseases National Center for Cardiovascular Diseases Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liujun","family":"Jia","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Experimental Study and Evaluation State Key Laboratory of Cardiovascular Disease National Clinical Research Center of Cardiovascular Diseases National Center for Cardiovascular Diseases Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Cardiac Arrhythmia Center State Key Laboratory of Cardiovascular Disease National Clinical Research Center of Cardiovascular Diseases National Center for Cardiovascular Diseases Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing 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