{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:16:01Z","timestamp":1790169361950,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,8,12]],"date-time":"2018-08-12T00:00:00Z","timestamp":1534032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81600213"],"award-info":[{"award-number":["81600213"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670222"],"award-info":[{"award-number":["81670222"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background\/Aims<\/jats:title><jats:p>Cardiac rupture (<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>) is a catastrophic complication of acute myocardial infarction (<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>). At present, there are no effective pharmacological strategies for preventing post\u2010<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> rupture. Here we investigated the effect of trimetazidine (<jats:styled-content style=\"fixed-case\">TMZ<\/jats:styled-content>) on post\u2010<jats:styled-content style=\"fixed-case\">MI CR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> models were induced by left coronary artery ligation in male C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6 mice. Animals allocated to the rupture incidence were closely monitored for 7\u00a0days; autopsy was performed once animals were found dead to determine the reason of death. Heart function was detected by echocardiography. Oxidative stress markers and matrix metalloproteinases (<jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>s) were analyzed by Western Blotting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">TMZ<\/jats:styled-content> markedly reduced the post\u2010<jats:styled-content style=\"fixed-case\">MI CR<\/jats:styled-content> incidence of mice. We found that the expression of metalloproteinase (<jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>) \u20102 and <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20109 in the <jats:styled-content style=\"fixed-case\">TMZ<\/jats:styled-content>\u2010treated group was significantly lower than the saline\u2010treated group. Further, <jats:styled-content style=\"fixed-case\">TMZ<\/jats:styled-content> markedly attenuated <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>\u2010induced oxidative stress. To investigate the mechanism of the effect of <jats:styled-content style=\"fixed-case\">TMZ<\/jats:styled-content> on <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>, we pretreated H9c2 cells with H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> and found that <jats:styled-content style=\"fixed-case\">TMZ<\/jats:styled-content> treatment markedly decreased H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>\u2010induced <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20102 and <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20109 expression. <jats:styled-content style=\"fixed-case\">TMZ<\/jats:styled-content> prevents <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> through inhibition of oxidative stress, which is attributable to the down\u2010regulation of <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20102, <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20109 expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings indicate that <jats:styled-content style=\"fixed-case\">TMZ<\/jats:styled-content> suppresses oxidative stress, inhibits <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20102 and <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20109 expression, and prevents <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> in mice with <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1755-5922.12460","type":"journal-article","created":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T03:32:55Z","timestamp":1531971175000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Trimetazidine suppresses oxidative stress, inhibits <scp>MMP<\/scp>\u20102 and <scp>MMP<\/scp>\u20109 expression, and prevents cardiac rupture in mice with myocardial infarction"],"prefix":"10.1111","volume":"36","author":[{"given":"Wei","family":"Gong","sequence":"first","affiliation":[{"name":"Emergency &amp; Critical Care Center Beijing Anzhen Hospital Capital Medical University  Beijing China"},{"name":"Beijing Institute of Heart Lung and Blood Vessel Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youcai","family":"Ma","sequence":"additional","affiliation":[{"name":"Emergency &amp; Critical Care Center Beijing Anzhen Hospital Capital Medical University  Beijing China"},{"name":"Beijing Institute of Heart Lung and Blood Vessel Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aobo","family":"Li","sequence":"additional","affiliation":[{"name":"Emergency &amp; Critical Care Center Beijing Anzhen Hospital Capital Medical University  Beijing China"},{"name":"Beijing Institute of Heart Lung and Blood Vessel Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Shi","sequence":"additional","affiliation":[{"name":"Emergency &amp; Critical Care Center Beijing Anzhen Hospital Capital Medical University  Beijing China"},{"name":"Beijing Institute of Heart Lung and Blood Vessel Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9867-3833","authenticated-orcid":false,"given":"Shaoping","family":"Nie","sequence":"additional","affiliation":[{"name":"Emergency &amp; Critical Care Center Beijing Anzhen Hospital Capital Medical University  Beijing China"},{"name":"Beijing Institute of Heart Lung and Blood Vessel Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq061"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2011.12.010"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000442815"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.01.035"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.86.5.580"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2015.10.022"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(00)00136-X"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)80461-5"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq181"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.109.165175"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm071"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2003.07.011"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000446640"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.223925"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13386"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-011-0606-1"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2013.03.027"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12346"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI21968"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M036533"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/13459"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI22304"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00246.2010"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn335"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2506"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000130526.20854.fa"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.7729"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-012-0305-1"},{"key":"e_1_2_7_30_1","first-page":"712","article-title":"Elevated levels of oxidative stress as a prognostic predictor of major adverse cardiovascular events in patients with coronary artery disease","volume":"19","author":"Vassalle C","year":"2012","journal-title":"J Atheroscler Thromb"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2013.03.009"}],"container-title":["Cardiovascular Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1755-5922.12460","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1755-5922.12460","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T04:15:57Z","timestamp":1695010557000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1755-5922.12460"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,12]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1111\/1755-5922.12460"],"URL":"https:\/\/doi.org\/10.1111\/1755-5922.12460","archive":["Portico"],"relation":{},"ISSN":["1755-5914","1755-5922"],"issn-type":[{"value":"1755-5914","type":"print"},{"value":"1755-5922","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,12]]},"assertion":[{"value":"2018-03-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12460"}}