{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T08:38:39Z","timestamp":1780475919272,"version":"3.54.1"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,8,15]],"date-time":"2018-08-15T00:00:00Z","timestamp":1534291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["ZZ11\u2010061"],"award-info":[{"award-number":["ZZ11\u2010061"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81373821"],"award-info":[{"award-number":["81373821"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>It is not clear whether treatment by vascular endothelial growth factor (<jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>) gene transfer can improve myocardial ischemia through a proangiogenesis mechanism and is effective against coronary artery disease (<jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>). We aimed to perform a systematic review and meta\u2010analysis of randomized controlled trials (<jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>s) that compared <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> gene therapy and standard treatments in <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We systematically searched the PubMed, Embase, and Cochrane databases and relevant references for <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>s (published up to May 2018; no language restrictions) and performed meta\u2010analysis using both fixed and random effects models. Our primary outcome measures were mortality and serious cardiac events. The secondary outcome measures were follow\u2010up left ventricular ejection fraction (<jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content>), change in <jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content> (\u0394<jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content>), and angina outcomes. The registration number is <jats:styled-content style=\"fixed-case\">CRD<\/jats:styled-content>42017058430.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 524 identified studies, 14 were eligible and were included in our analysis. At a mean follow\u2010up of 6\u00a0months, <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> gene therapy demonstrated a decreased risk of serious cardiac events (11.7% vs 21.2%, relative risk: 0.56; 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>): 0.37, 0.84; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.005) and a slight improvement in follow\u2010up <jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content> (weighted mean difference: 1.95; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.28, 2.62). Furthermore, <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> gene therapy using adenoviral vectors showed more potential benefit in terms of the risk of serious cardiac events, \u0394<jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content>, and Canadian Cardiovascular Society angina class. Nevertheless, mortality and angina frequency scores were not different.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Vascular endothelial growth factor gene therapy appears to be safe and effective regarding serious cardiac events, with greater benefit when using adenoviral vectors. This meta\u2010analysis highlights the need for further exploration in these areas.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1755-5922.12461","type":"journal-article","created":{"date-parts":[[2018,7,23]],"date-time":"2018-07-23T11:09:45Z","timestamp":1532344185000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Vascular endothelial growth factor gene transfer therapy for coronary artery disease: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6824-3055","authenticated-orcid":false,"given":"Rong","family":"Yuan","sequence":"first","affiliation":[{"name":"Graduate School Beijing University of Chinese Medicine  Beijing China"},{"name":"Laboratory of Cardiovascular Diseases Xiyuan Hospital China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiqi","family":"Xin","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Diseases Xiyuan Hospital China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weili","family":"Shi","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Diseases Xiyuan Hospital China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Cardiovascular Department Beijing Hospital of TCM Affiliated to the Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon\u2010M.","family":"Lee","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences University of Macau  Macao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puiman","family":"Hoi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences University of Macau  Macao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[{"name":"Laboratory of Neurodegenerative Diseases Xuanwu Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Traditional Chinese Medicine Department The Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihong","family":"Cong","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Diseases Xiyuan Hospital China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keji","family":"Chen","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Diseases Xiyuan Hospital China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2014.26"},{"key":"e_1_2_9_3_1","first-page":"293","volume-title":"World Health Statistics 2016. 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