{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:25:56Z","timestamp":1753878356598,"version":"3.41.2"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,8,28]],"date-time":"2018-08-28T00:00:00Z","timestamp":1535414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","award":["XX02\/11"],"award-info":[{"award-number":["XX02\/11"]}],"id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2018,12]]},"abstract":"Summary<\/jats:title>Aim<\/jats:title>To evaluate the prevalence and impact of the prescribing of an evidence\u2010based cardiac medication (EBM<\/jats:styled-content>) combination on 1\u2010month, 6\u2010months, and 12\u2010months all\u2010cause mortality in patients with acute coronary syndrome (ACS<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>Data were analyzed from 3681 consecutive patients diagnosed with ACS<\/jats:styled-content> admitted to 29 hospitals in 4 Middle Eastern countries from January 2012 to January 2013. The EBM<\/jats:styled-content> combination consisted of concurrent prescribing of an antiplatelet therapy, angiotensin\u2010converting enzyme inhibitor (ACEI<\/jats:styled-content>) or angiotensin II<\/jats:styled-content> receptor blocker (ARB<\/jats:styled-content>), \u03b2\u2010blocker, and a statin, at hospital discharge. Analyses were performed using univariate and multivariate statistical techniques.<\/jats:p><\/jats:sec>Results<\/jats:title>The overall mean age of the cohort was 60\u00a0\u00b1\u00a013\u00a0years, 66% (n\u00a0=\u00a02436) were males. In all, 69% (n\u00a0=\u00a02542) of the patients received the quadruple EBM<\/jats:styled-content> combination at discharge. Two\u2010way interactions between EBM<\/jats:styled-content> and age (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.824), EBM<\/jats:styled-content> and GRACE<\/jats:styled-content> risk score (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.873) and between EBM<\/jats:styled-content> and discharge diagnosis (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.836) were all not statistically significant. Adjusting for demographic and clinical characteristics, the prescribing of EBM<\/jats:styled-content> combination was associated with significantly lower cumulative all\u2010cause mortality at 1\u2010month (adjusted OR<\/jats:styled-content> (aOR<\/jats:styled-content>), 0.43; 95% confidence interval (CI<\/jats:styled-content>): 0.24\u20100.79; P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.007), which persisted at 6\u2010months (aOR<\/jats:styled-content>, 0.52; 95% CI<\/jats:styled-content>: 0.38\u20100.72; P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.001) and at 12\u2010months of follow\u2010up (aOR<\/jats:styled-content>, 0.58; 95% CI<\/jats:styled-content>: 0.44\u20100.75; P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.001) posthospital discharge.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Among patients discharged after an ACS<\/jats:styled-content> event, concurrent EBM<\/jats:styled-content> prescribing was associated with lower all\u2010cause mortality that persists for up to 12\u2010months posthospital discharge. The relative benefits of EBM<\/jats:styled-content>s were also consistent across age, GRACE<\/jats:styled-content> risk score, and discharge diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1755-5922.12463","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T09:02:52Z","timestamp":1533632572000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effect of evidence\u2010based cardiac drug therapy on mortality in patients with acute coronary syndrome: Findings from the Gulf COAST<\/scp> registry"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3626-4230","authenticated-orcid":false,"given":"Ibrahim","family":"Al\u2010Zakwani","sequence":"first","affiliation":[{"name":"Department of Pharmacology & Clinical Pharmacy College of Medicine & Health Sciences Sultan Qaboos University Muscat Oman"},{"name":"Gulf Health Research Muscat Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Zubaid","sequence":"additional","affiliation":[{"name":"Department of Medicine Faculty of Medicine Kuwait University Kuwait City Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alawi A.","family":"Alsheikh\u2010Ali","sequence":"additional","affiliation":[{"name":"College of Medicine Mohammed Bin Rashid University of Medicine and Health Sciences Dubai UAE"},{"name":"Institute of Cardiac Sciences Sheikh Khalifa Medical City Abu Dhabi UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wael","family":"Almahmeed","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute Cleveland Clinic Abu Dhabi Abu Dhabi UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wafa","family":"Rashed","sequence":"additional","affiliation":[{"name":"Department of Medicine Mubarak Al\u2010Kabeer Hospital, Ministry of Health Kuwait City Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.302782"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.15.158303"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.02.013"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.02.011"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx393"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000112577.69066.CB"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.07.040"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2011.08.024"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000355160"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.12816\/0003194"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874192401408010088"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.05.001"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003319710369794"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113284"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.143.1.7063747"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003319710394163"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2005.01.058"},{"issue":"509","key":"e_1_2_8_19_1","first-page":"e1","article-title":"Evidence\u2010based medication use among Chinese patients with acute coronary syndromes at the time of hospital discharge and 1\u00a0year after hospitalization: results from the Clinical Pathways for Acute Coronary Syndromes in China (CPACS) study","volume":"157","author":"Bi Y","year":"2009","journal-title":"Am Heart J"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl196"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.080295"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.12.1430"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.324.7329.71"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.318.7200.1730"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12948-0"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09327-3"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200001203420301"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.5414\/CP201667"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2011.02.009"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.03.013"}],"container-title":["Cardiovascular Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1755-5922.12463","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1755-5922.12463","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1755-5922.12463","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1755-5922.12463","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T02:59:23Z","timestamp":1694401163000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1755-5922.12463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,28]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1111\/1755-5922.12463"],"URL":"https:\/\/doi.org\/10.1111\/1755-5922.12463","archive":["Portico"],"relation":{},"ISSN":["1755-5914","1755-5922"],"issn-type":[{"type":"print","value":"1755-5914"},{"type":"electronic","value":"1755-5922"}],"subject":[],"published":{"date-parts":[[2018,8,28]]},"assertion":[{"value":"2018-04-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12463"}}