{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T01:21:31Z","timestamp":1768008091522,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,9,11]],"date-time":"2018-09-11T00:00:00Z","timestamp":1536624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Health and Medical Research Council of Australia","award":["1066242"],"award-info":[{"award-number":["1066242"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2018,12]]},"abstract":"Summary<\/jats:title>Aim<\/jats:title>Hospitalized heart failure (HF<\/jats:styled-content>) patients have a poor prognosis postdischarge. We determined whether renin\u2010angiotensin system inhibitors (RASI<\/jats:styled-content>) and \u03b2\u2010blockers dispensed to patients within 60\u00a0days post\u2010HF<\/jats:styled-content> hospital discharge are associated with improved 1\u2010year survival.<\/jats:p><\/jats:sec>Methods<\/jats:title>A retrospective population\u2010based study was conducted in 4897 seniors, aged 65\u201084\u00a0years, alive at 60\u00a0days postindex HF<\/jats:styled-content> hospitalization in Western Australia over 2003\u20102008. Dispensing of RASI<\/jats:styled-content> and \u03b2\u2010blocker dispensing was identified from the Pharmaceutical Benefits Scheme claims database linked to hospital admission and death records.<\/jats:p><\/jats:sec>Results<\/jats:title>At 1\u2010year posthospital discharge, the all\u2010cause mortality and all\u2010cause death or HF<\/jats:styled-content> rehospitalization rate was 13.5% (n\u00a0=\u00a0663) and 24.4% (n\u00a0=\u00a01193), respectively. Postdischarge RASI<\/jats:styled-content> and \u03b2\u2010blocker were dispensed in 77.4% and 53.0% of patients, respectively. Their use was associated with a lower inverse probability treatment weighted (IPTW<\/jats:styled-content>) HR<\/jats:styled-content> for 1\u2010year mortality of 0.70, 95% CI<\/jats:styled-content> 0.61\u20100.81 and 0.79, 95% CI<\/jats:styled-content> 0.68\u20100.92, respectively (both P<\/jats:italic>\u00a0<\u00a00.0001), with a survival advantage most evident in the subgroup (70.1%) of patients with ischemic HF<\/jats:styled-content>. In the overall cohort, these therapies were also associated with reduced IPTW HR<\/jats:styled-content>s for all\u2010cause death or HF<\/jats:styled-content> rehospitalization (both P<\/jats:italic>\u00a0<\u00a00.005) but not for HF<\/jats:styled-content> rehospitalization exclusively. Use of a \u03b2\u2010blocker was associated with a reduced IPTW HR<\/jats:styled-content> for HF<\/jats:styled-content> rehospitalization in the ischemic HF<\/jats:styled-content> subgroup only.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In a cohort of senior patients hospitalized with HF<\/jats:styled-content>, dispensing of a RASI<\/jats:styled-content> or \u03b2\u2010blocker within 60\u00a0days postdischarge is associated with a 1\u2010year survival benefit. Early postdischarge support programs after recent HF<\/jats:styled-content> hospitalization should include measures to optimize adherence to evidence\u2010based medications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1755-5922.12464","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T14:49:33Z","timestamp":1534949373000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Evidence\u2010based pharmacotherapies used in the postdischarge phase are associated with improved one\u2010year survival in senior patients hospitalized with heart failure"],"prefix":"10.1111","volume":"36","author":[{"given":"Xiwen","family":"Qin","sequence":"first","affiliation":[{"name":"School of Population and Global Health The University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4468-6097","authenticated-orcid":false,"given":"Joseph","family":"Hung","sequence":"additional","affiliation":[{"name":"Medical School Sir Charles Gairdner Hospital Unit The University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Knuiman","sequence":"additional","affiliation":[{"name":"School of Population and Global Health The University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiew\u2010Hwa K.","family":"Teng","sequence":"additional","affiliation":[{"name":"School of Population and Global Health The University of Western Australia Perth Western Australia Australia"},{"name":"National Heart Centre Singapore Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Briffa","sequence":"additional","affiliation":[{"name":"School of Population and Global Health The University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3639-0787","authenticated-orcid":false,"given":"Frank M.","family":"Sanfilippo","sequence":"additional","affiliation":[{"name":"School of Population and Global Health The University of Western Australia Perth Western Australia 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