{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T03:58:52Z","timestamp":1790135932283,"version":"4.0.1"},"reference-count":10,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,9,29]],"date-time":"2018-09-29T00:00:00Z","timestamp":1538179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002924","name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Optimal diuretic treatment of patients with refractory congestive heart failure (CHF) remains to be elucidated. In this work, we aimed to evaluate the serial changes of functional class and surrogates of fluid overload (weight and antigen carbohydrate 125) after addition of oral acetazolamide in patients with refractory CHF. Likewise, serial changes in renal function, serum electrolytes and pH were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This is an observational retrospective study in which 25 ambulatory patients with refractory CHF that received acetazolamide in addition to standard intensive diuretic strategy were evaluated. Longitudinal assessment of New York Heart Association (NYHA) functional class and biomarkers was analyzed using joint modelling of longitudinal and survival data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients showed NYHA class III\/IV at baseline. After prescription of acetazolamide, a total of 125 outpatient visits were recorded [median visits per patient: 6 (IQR\u00a0=\u00a03\u20107)] during a median follow\u2010up of 152\u00a0days (IQR\u00a0=\u00a080\u2010353). A significant decrease in NYHA class, weight, and antigen carbohydrate 125 was observed. On the other hand, estimated glomerular filtration rate increased over time. No significant changes in systolic blood pressure, serum sodium, potassium, amino\u2010terminal pro\u2010brain natriuretic peptide, and pH occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In a cohort of patients with refractory CHF treated with an intensive diuretic treatment, the addition of acetazolamide was associated with improvement in functional class and surrogates of fluid overload.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1755-5922.12465","type":"journal-article","created":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T01:53:40Z","timestamp":1536285220000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Use of acetazolamide in the treatment of patients with refractory congestive heart failure"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1672-7119","authenticated-orcid":false,"given":"Julio","family":"N\u00fa\u00f1ez","sequence":"first","affiliation":[{"name":"Cardiology Department Hospital Cl\u00ednico Universitario de Valencia INCLIVA Departamento de Medicina Universitat de Val\u00e8ncia Valencia Spain"},{"name":"CIBER in Cardiovascular Diseases (CIBERCV) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Heredia","sequence":"additional","affiliation":[{"name":"Cardiology Department Hospital Cl\u00ednico Universitario de Valencia INCLIVA Departamento de Medicina Universitat de Val\u00e8ncia Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Pay\u00e1","sequence":"additional","affiliation":[{"name":"Cardiology Department Hospital Cl\u00ednico Universitario de Valencia INCLIVA Departamento de Medicina Universitat de Val\u00e8ncia Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Sanchis","sequence":"additional","affiliation":[{"name":"Cardiology Department Hospital Cl\u00ednico Universitario de Valencia INCLIVA Departamento de Medicina Universitat de Val\u00e8ncia Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"del Prado","sequence":"additional","affiliation":[{"name":"Cardiology Department Hospital Universitario Ram\u00f3n y Cajal Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gema","family":"Mi\u00f1ana","sequence":"additional","affiliation":[{"name":"Cardiology Department Hospital Cl\u00ednico Universitario de Valencia INCLIVA Departamento de Medicina Universitat de Val\u00e8ncia Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Santas","sequence":"additional","affiliation":[{"name":"Cardiology Department Hospital Cl\u00ednico Universitario de Valencia INCLIVA Departamento de Medicina Universitat de Val\u00e8ncia Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"de la Espriella","sequence":"additional","affiliation":[{"name":"Cardiology Department Hospital Cl\u00ednico Universitario de Valencia INCLIVA Departamento de Medicina Universitat de Val\u00e8ncia Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"N\u00fa\u00f1ez","sequence":"additional","affiliation":[{"name":"Cardiology Department Hospital Cl\u00ednico Universitario de Valencia INCLIVA Departamento de Medicina Universitat de Val\u00e8ncia Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Sanchis","sequence":"additional","affiliation":[{"name":"Cardiology Department Hospital Cl\u00ednico Universitario de Valencia INCLIVA Departamento de Medicina Universitat de Val\u00e8ncia Valencia Spain"},{"name":"CIBER in Cardiovascular Diseases (CIBERCV) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoni","family":"Bay\u00e9s\u2010Gen\u00eds","sequence":"additional","affiliation":[{"name":"CIBER in Cardiovascular Diseases (CIBERCV) Madrid Spain"},{"name":"Heart Institute Hospital Universitari Germans Trias i Pujol Badalona Spain"},{"name":"Department of Medicine Universitat Autonoma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2015.06.004"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2016.06.007"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/2048872618768488"},{"key":"e_1_2_8_5_1","first-page":"234","article-title":"Current use of acetazolamide as a diuretic: usefulness in refractory edema and in aldosterone\u2010antagonist\u2010related hyperkalemia","volume":"28","author":"Caramelo C","year":"2008","journal-title":"Nefrologia"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-017-0577-1"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.35"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw128"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.06.034"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/2048872616649757"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/AC.70.3.3080630"}],"container-title":["Cardiovascular 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