{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:44:59Z","timestamp":1787168699396,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T00:00:00Z","timestamp":1542067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01HL086932"],"award-info":[{"award-number":["1R01HL086932"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["UL1 TR000038"],"award-info":[{"award-number":["UL1 TR000038"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Blood donation has been proposed as a potential therapy to reduce risk of cardiovascular disease, but the effects of phlebotomy on vascular function in human subjects have not been well characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We conducted a prospective randomized double\u2010blind study to determine the effects of serial phlebotomy on vascular endothelial function in the brachial artery. Eighty\u2010four iron\u2010replete, non\u2010anemic subjects were randomly assigned to one of three study treatment groups: (a) four serial phlebotomy procedures each followed by intravenous infusion of placebo normal saline; (b) four serial phlebotomy procedures each followed by intravenous infusion to replete lost iron; and (c) four serial sham phlebotomy procedures each followed by intravenous infusion of placebo normal saline. Assigned phlebotomy procedures were conducted at 56\u2010day intervals. We measured brachial artery reactivity (BAR, %) in response to transient oxidative stress induced by oral methionine with high\u2010resolution duplex ultrasound imaging before and one week after the fourth study phlebotomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Before phlebotomy, oral methionine decreased BAR by \u22122.04% (95% CI \u22122.58%, \u22121.50%),\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) with no significant difference between groups (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.42). After phlebotomy, the BAR response to oral methionine did not significantly change between groups (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.53). Brachial artery nitroglycerin\u2010mediated dilation did not change in response to phlebotomy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Four serial phlebotomy procedures over six months with or without intravenous iron supplementation did not alter vascular endothelial function in the brachial artery when compared with sham phlebotomy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1755-5922.12470","type":"journal-article","created":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T13:04:13Z","timestamp":1540040653000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effects of serial phlebotomy on vascular endothelial function: Results of a prospective double\u2010blind randomized study"],"prefix":"10.1111","volume":"36","author":[{"given":"Qurat\u2010ul\u2010ain","family":"Jelani","sequence":"first","affiliation":[{"name":"Department of Medicine, New York University School of Medicine New York University Langone Medical Center New York City New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhisham","family":"Harchandani","sequence":"additional","affiliation":[{"name":"Department of Medicine, New York University School of Medicine New York University Langone Medical Center New York City New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritchard G.","family":"Cable","sequence":"additional","affiliation":[{"name":"American Red Cross Farmington Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Population Health New York University Langone Medical Center New York City New 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