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Current guidelines indicate that controlling and lowering BP promotes cardiovascular (CV) risk reduction. Among antihypertensive agents, angiotensin receptor blockers (ARBs) are characterized by an efficacy profile equivalent to other antihypertensive agents and are provided with excellent tolerability and low discontinuation rates during chronic treatments. Moreover, CV outcomes are reduced by ARBs. Olmesartan is a long\u2010lasting ARB which proved to achieve a comparable or more effective action in lowering BP when compared to other ARBs. Olmesartan, in fact, displayed a larger and more sustained antihypertensive effect over the 24\u00a0hours, with a buffering effect on short\u2010term BP variability. These are important features which differentiate olmesartan from the other principles of the same class and that may help to control the increased CV risk in the presence of high BP variability. Olmesartan shows similar benefits as other ARBs in terms of all\u2010cause and CV mortality, and a favorable tolerability profile. Combination of olmesartan with long\u2010lasting calcium\u2010channel blockers and thiazide diuretics represents a rational and effective therapy. Thus, ARBs, including olmesartan, represent one of the most effective and safe treatments for patients with arterial hypertension.<\/jats:p>","DOI":"10.1111\/1755-5922.12471","type":"journal-article","created":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T11:14:37Z","timestamp":1540466077000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Management of arterial hypertension with angiotensin receptor blockers: Current evidence and the role of olmesartan"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7124-2096","authenticated-orcid":false,"given":"Stefano","family":"Omboni","sequence":"first","affiliation":[{"name":"Clinical Research Unit Italian Institute of Telemedicine Varese Italy"},{"name":"Scientific Research Department of Cardiology, Science and Technology Park for Biomedicine Sechenov First Moscow State Medical University  Moscow Russian 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