{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:42:24Z","timestamp":1787013744712,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,10,22]],"date-time":"2012-10-22T00:00:00Z","timestamp":1350864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Diet plays a significant role in the development of gout and hyperuricemia. Gout and hyperuricemia have likewise been associated with the development of cardiovascular disease and metabolic syndrome. Epidemiological studies have shown that certain foods influence levels of serum uric acid and the risk for development of gout.This article reviews the influence of dietary factors on serum uric acid levels and risk of gout, as well as the role of urate transporters in the development of hyperuricemia and gout.Various epidemiological studies have shown the effects of certain foods on the risk of developing gout and hyperuricemia. Low\u2010fat dairy products, purine\u2010rich vegetables, whole grains, nuts and legumes, and less sugary fruits, coffee and vitamin C supplements decrease the risk, whereas intake of red meat, fructose\u2010containing beverages and alcohol increase the risk of gout. There is also an increased although basic understanding of the effects of vitamin C, alcohol and fructose on urate transporters. Certain foods can lead to a decreased or increased risk of development of gout and hyperuricemia. Advances have established the interplay of certain foods on urate transporters and renal handling of urate. More studies, especially prospective ones, are needed to increase our understanding of the roles of foods and urate transporters and other molecular mechanisms on the risk of developing gout and hyperuricemia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.12010","type":"journal-article","created":{"date-parts":[[2012,10,22]],"date-time":"2012-10-22T02:26:12Z","timestamp":1350872772000},"page":"499-506","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["The interplay between diet, urate transporters and the risk for gout and hyperuricemia: current and future directions"],"prefix":"10.1111","volume":"15","author":[{"given":"Karina D.","family":"Torralba","sequence":"first","affiliation":[{"name":"Division of Rheumatology Keck School of Medicine University of Southern California Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emerson","family":"De Jesus","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of California\u2010San Francisco Fresno California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shylaja","family":"Rachabattula","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Keck School of Medicine University of Southern California Los Angeles California 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