{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T10:01:57Z","timestamp":1697536917025},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,10,20]],"date-time":"2012-10-20T00:00:00Z","timestamp":1350691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2013,2]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>Ankylosing spondylitis (AS<\/jats:styled-content>) is a chronic rheumatic disorder with gender differences. The aim of study was to investigate the association between polymorphisms of the androgen receptor<\/jats:italic> (AR<\/jats:styled-content><\/jats:italic>) gene and the susceptibility to AS<\/jats:styled-content> in T<\/jats:styled-content>aiwanese men of H<\/jats:styled-content>an C<\/jats:styled-content>hinese descent.<\/jats:p><\/jats:sec>Methods<\/jats:title>We conducted a case\u2010control study with 92 male AS<\/jats:styled-content> patients and 108 healthy controls. Trinucleotide (CAG<\/jats:styled-content> and GGC<\/jats:styled-content>) repeats and seven single nucleotide polymorphisms (SNP<\/jats:styled-content>s) rs962458, rs6152, rs1204038, rs5918757, rs2361634, rs6624304 and rs1337080 in the AR<\/jats:styled-content><\/jats:italic> gene were genotyped.<\/jats:p><\/jats:sec>Results<\/jats:title>We found that only one patient had polymorphic SNP<\/jats:styled-content>s of the AR<\/jats:styled-content><\/jats:italic> gene. None of the genotyped SNP<\/jats:styled-content>s in the AR<\/jats:styled-content><\/jats:italic> gene, originally found in Caucasians, was polymorphic in the Taiwanese men. Neither CAG<\/jats:styled-content> nor GGC<\/jats:styled-content> repeat lengths in the AR<\/jats:styled-content><\/jats:italic> gene had a significant relationship with human leukocyte antigen (HLA<\/jats:styled-content>)\u2010B<\/jats:styled-content>27 positivity or disease severity in AS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>There were no differences in CAG<\/jats:styled-content> and GGC<\/jats:styled-content> lengths in the AR<\/jats:styled-content><\/jats:italic> gene between AS<\/jats:styled-content> and the controls. None of the genotyped SNP<\/jats:styled-content>s in AR<\/jats:styled-content><\/jats:italic> gene are detected to be polymorphic in male T<\/jats:styled-content>aiwanese, which indicates that the effect of AR<\/jats:styled-content><\/jats:italic> gene on AS<\/jats:styled-content> may be ethnic\u2010specific and may be conserved in East Asians compared to Caucasian populations. Still, additional studies using large sets of subjects deserve further attention, since our sample size was small with limited statistical power and supporting evidence for association between the AR<\/jats:styled-content><\/jats:italic> gene and AS<\/jats:styled-content> risk in the J<\/jats:styled-content>apanese population exists.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12011","type":"journal-article","created":{"date-parts":[[2012,10,20]],"date-time":"2012-10-20T06:42:24Z","timestamp":1350715344000},"page":"81-87","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Androgen receptor genetic variants in male patients with ankylosing spondylitis in T<\/scp>aiwan"],"prefix":"10.1111","volume":"16","author":[{"given":"Shan\u2010Fu","family":"Yu","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Allergy and Immunology, Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital Chang\u2010Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Hsiang","family":"Hsu","sequence":"additional","affiliation":[{"name":"Program for Population Genetics Harvard School of Public Health Boston Massachusetts USA"},{"name":"Hebrew Senior Life Institute for Aging Research and Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tien\u2010Tsai","family":"Cheng","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Allergy and Immunology, Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital Chang\u2010Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han\u2010Ming","family":"Lai","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Allergy and Immunology, Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital Chang\u2010Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung\u2010Jen","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Allergy and Immunology, Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital Chang\u2010Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010Yo","family":"Kang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medical Sciences and Center for Menopause and Reproductive Research Kaohsiung Chang Gung Memorial Hospital, Chang Gung University, College of Medicine Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,10,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199801)41:1<58::AID-ART8>3.0.CO;2-G"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2368"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60635-7"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.bor.0000231899.81677.04"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200106)44:6<1396::AID-ART233>3.0.CO;2-A"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780401015"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel443"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-002-0237-4"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.43.4.570"},{"key":"e_1_2_6_11_1","first-page":"531","article-title":"Sex hormones, immune responses, and autoimmune diseases. Mechanisms of sex hormone action","volume":"121","author":"Ansar Ahmed S","year":"1985","journal-title":"Am J Pathol"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1996.tb16239.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb07622.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(05)70174-5"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.55.11.811"},{"key":"e_1_2_6_16_1","first-page":"401","article-title":"Accelerated deaths from systemic lupus erythematosus in NZB x NZW F1 mice treated with the testosterone\u2010blocking drug flutamide","volume":"124","author":"Walker S","year":"1994","journal-title":"J Lab Clin Med"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb07658.x"},{"key":"e_1_2_6_18_1","first-page":"671","article-title":"Androgenic status and sexual function in males with rheumatoid arthritis and ankylosing spondylitis","volume":"60","author":"Gordon D","year":"1986","journal-title":"Q J Med"},{"issue":"6","key":"e_1_2_6_19_1","first-page":"S52","article-title":"No alterations of serum levels of adrenal and gonadal hormones in patients with ankylosing spondylitis","volume":"20","author":"Straub R","year":"2002","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3353726"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3353727"},{"key":"e_1_2_6_22_1","first-page":"388","article-title":"Mechanisms and clinical relevance of androgens and androgen receptor actions","volume":"26","author":"Kang H","year":"2003","journal-title":"Chang Gung Med J"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/22.15.3181"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.10.12.1527"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.20128"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-007-0616-z"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/39.5.530"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2010.09.006"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270401"},{"key":"e_1_2_6_30_1","first-page":"2286","article-title":"A new approach to defining disease status in ankylosing spondilylitis: the Bath ankylosing spondylitis activity index","volume":"21","author":"Garret S","year":"1994","journal-title":"J Rheumatol"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-007-0573-6"},{"key":"e_1_2_6_32_1","first-page":"2281","article-title":"A new approach to defining functional ability in ankylosing spondylitis: the development of the Bath ankylosing spondylitis functional index","volume":"21","author":"Calin A","year":"1994","journal-title":"J Rheumatol"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199812)41:12<2263::AID-ART23>3.0.CO;2-I"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1086\/427224"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1159\/000071807"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.11.961"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2007.17"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12041-008-0010-x"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199804)41:4<588::AID-ART5>3.0.CO;2-0"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-009-0668-z"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1756-185X.12011","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.12011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T03:15:42Z","timestamp":1697426142000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.12011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,20]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["10.1111\/1756-185X.12011"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.12011","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,20]]},"assertion":[{"value":"2012-10-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}