{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T20:05:34Z","timestamp":1778875534740,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,10,27]],"date-time":"2012-10-27T00:00:00Z","timestamp":1351296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> findings that may predict unfavorable outcomes in the patients with neuro\u2010Beh\u00e7et's disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>All consecutive patients referred from 2002 to 2009 to the Beh\u00e7et Clinic at Nemazee Hospital, Shiraz, Iran, who fulfilled International Study Group criteria for Beh\u00e7et's disease and diagnosed as having neuro\u2010Beh\u00e7et's disease, were enrolled into this study. Characteristics of initial brain <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> were studied in patients with different courses of neuro\u2010Beh\u00e7et's disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Initial <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>s of 58 patients (31 women) with a mean\u00a0\u00b1\u00a0<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> age of 38.9\u00a0\u00b1\u00a09.7\u00a0years were reviewed. Forty\u2010nine (84%) patients had parenchymal and nine (16%) had non\u2010parenchymal neuro\u2010Beh\u00e7et's disease. Of those patients with parenchymal neuro\u2010Beh\u00e7et's disease, 15 (31%) had monophasic, 13 (27%) polyphasic and 10 (20%) progressive courses; 11 (22%) had only headache attributed to Beh\u00e7et's disease. The most common sites of involvement in patients with parenchymal neuro\u2010Beh\u00e7et's disease were periventricular and superficial cerebral white matter, midbrain and pons, respectively. Of those with parenchymal involvement, 12 (24%) had extension of lesions, seven (14%) had contrast enhancement, 12 (24%) had black holes and five (10%) had brainstem atrophy. Patients with a progressive course had a significantly (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.017; <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a018, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.7\u201319.1) higher rate of brainstem atrophy than those with a non\u2010progressive course (monophasic or polyphasic).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Presence of brainstem atrophy in the initial <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>s may predict a progressive course in patients with neuro\u2010Beh\u00e7et's disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12013","type":"journal-article","created":{"date-parts":[[2012,10,27]],"date-time":"2012-10-27T08:42:51Z","timestamp":1351327371000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Magnetic 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