{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T13:57:48Z","timestamp":1765807068003},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,12,15]],"date-time":"2012-12-15T00:00:00Z","timestamp":1355529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess effects of ankylosing spondylitis (<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>) on working life and physical activity in Australia; to quantify changes in working life and physical activity that occur after anti\u2010tumor necrosis factor\u2010alpha (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1) treatment; and to assess efficacy of anti\u2010<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 therapy for <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> in an Australian context.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a multi\u2010centre observational study of people with <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> on anti\u2010<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 therapy. All participants satisfied the New York Modified Criteria and had active and refractory disease at anti\u2010<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 therapy commencement. Participation involved a standardized interview, a metrology assessment, assessment of disease remission and medical record review. Interviews and patients' records were used to compare working life (employment, sick leave and productivity) and physical activity (participation rate, hours\/week, and physical intensity) between the pre\u2010<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>, post\u2010<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> and post\u2010anti\u2010<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 therapy periods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010two patients took part. Participants were on average 44.8\u00a0years old, predominately male (86.5%) and had been on anti\u2010<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 therapy for 29\u00a0months; 39% were in partial remission and 75% had 50% reduction in the <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ath <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>nkylosing <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>pondylitis <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>isease <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ctivity <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>ndex (<jats:styled-content style=\"fixed-case\">BASDAI<\/jats:styled-content>). Responders to anti\u2010<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 therapy were 10.5\u00a0years younger than non\u2010responders (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.004). Post\u2010anti\u2010<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 therapy participants gained 6.6\u00a0h\/week of work (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.02), and productivity improved 31% (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001) compared to immediately prior to commencing treatment. Physical activity participation increased from 71% to 85% (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.039) and activity intensity increased by 33% (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.002) post\u2010treatment. Participants gained 1.8\u00a0h\/week of sport (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.001) and 2.2\u00a0h\/week of recreational physical activity (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Australians with <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> have their working life and physical activity severely affected by this disease. Treatment with anti\u2010<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 therapy results in significant improvement in these parameters.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12018","type":"journal-article","created":{"date-parts":[[2012,12,15]],"date-time":"2012-12-15T05:37:18Z","timestamp":1355549838000},"page":"165-172","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Working life and physical activity in ankylosing spondylitis pre and post anti\u2010tumor necrosis factor\u2010alpha therapy"],"prefix":"10.1111","volume":"17","author":[{"given":"David S.","family":"Prince","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of New South Wales Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis E.","family":"McGuigan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of New South Wales Sydney New South Wales Australia"},{"name":"Combined Rheumatology Practice Miranda New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen E.","family":"McGirr","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Sydney Sydney"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,12,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60635-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-136-12-200206180-00011"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-002-0237-4"},{"key":"e_1_2_7_5_1","volume-title":"Fit for Work? 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