{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T08:28:44Z","timestamp":1770884924392,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,1,28]],"date-time":"2013-01-28T00:00:00Z","timestamp":1359331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study was designed to evaluate iron deficiency as a predisposing factor for resistant oral aphthosis in patients with Behcet's disease (<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a case control study 220 consecutive <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> patients with oral aphthosis were enrolled. All patients had been treated for at least 3\u00a0months. They were divided into two groups according to their treatment response (75 patients in the Case and 145 in the Control group<jats:italic>)<\/jats:italic>. Demographic and clinical characteristics of the disease, serum iron, total iron binding capacity and serum ferritin were determined in each patient. We used independent <jats:italic>t<\/jats:italic>\u2010test and Mann\u2013Whitney <jats:italic>U<\/jats:italic>\u2010test to compare the quantitative variables and chi\u2010square test for qualitative variables. Odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) and confidence interval at 95% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) were calculated for each item.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no significant difference between the two groups in demographics or clinical characteristics of the disease. We found iron deficiency in 72 patients (32.7%, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 6.2), higher in the Case group than Control (39.2% <jats:italic>vs<\/jats:italic>. 30.1%; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.17). Despite the higher frequency of iron deficiency in men (26.8% <jats:italic>vs<\/jats:italic>. 14.5%), the difference was not statistically significant (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.09). Multivariate logistic regression analysis showed that none of the iron deficiency or sex variables could predict the development of resistant oral aphthosis. The <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> for iron deficiency was 1.52 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.81\u20132.86) and for male sex was 1.04 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.56\u20131.91).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite the higher frequency of iron deficiency in <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> patients with resistant oral aphthosis, we were not able to attribute this resistance to this deficiency.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12045","type":"journal-article","created":{"date-parts":[[2013,1,28]],"date-time":"2013-01-28T06:56:08Z","timestamp":1359356168000},"page":"425-429","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Iron deficiency state in resistant oral aphthosis of <scp>B<\/scp>ehcet's disease"],"prefix":"10.1111","volume":"17","author":[{"given":"Taraneh","family":"Dormohammadi Toosi","sequence":"first","affiliation":[{"name":"Behcet's Disease Unit Rheumatology Research Center Shariati Hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farhad","family":"Shahram","sequence":"additional","affiliation":[{"name":"Behcet's Disease Unit Rheumatology Research Center Shariati Hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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