{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T17:03:33Z","timestamp":1770915813528,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,4,26]],"date-time":"2013-04-26T00:00:00Z","timestamp":1366934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Gout is a common condition which is mainly treated with the hypo\u2010uricemic agent, allopurinol. Although allopurinol is generally a well\u2010tolerated drug, there is a small risk of developing potentially fatal complications, such as allopurinol hypersensitivity syndrome. Recent advances in pharmacogenomics have made possible the identification of genes which confer susceptibility to specific drugs. A recent multi\u2010national case\u2010control study has reported allopurinol as the most common drug associated with Stevens\u2010Johnson syndrome and toxic epidermal necrolysis. Several studies have established a strong association between the human leukocyte antigen (<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>)\u2010B*5801 gene and development of Stevens\u2010Johnson syndrome and toxic epidermal necrolysis. The allele frequency of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B*5801 is highest in the South East Asian population.Since other hypo\u2010uricemic agents are available, patients may wish to have <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B*5801 testing before being started on allopurinol. As the test for <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B*5801 is expensive, time\u2010consuming and only available in selected laboratories, there is a need to evaluate the utility and cost\u2010effectiveness of this test in our region.<\/jats:p>","DOI":"10.1111\/1756-185x.12050","type":"journal-article","created":{"date-parts":[[2013,4,26]],"date-time":"2013-04-26T08:54:42Z","timestamp":1366966482000},"page":"254-257","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["HLA\u2010B*5801: utility and cost\u2010effectiveness in the <scp>A<\/scp>sia\u2010<scp>P<\/scp>acific <scp>R<\/scp>egion"],"prefix":"10.1111","volume":"16","author":[{"given":"Siaw Ing","family":"Yeo","sequence":"first","affiliation":[{"name":"Division of Rheumatology and Clinical Immunology LKS Faculty of Medicine The University of Hong Kong Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4,26]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2368"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.40.3.245"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/106002809302700317"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-197911000-00004"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701033"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290111"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/38.12.1301"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.2003.00062.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0409500102"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e328330a3b8"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.2217\/14622416.9.11.1617"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e32834282b8"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr060"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e3282f3ef9c"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-12-118"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200009073431006"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.11.046"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1098-3015(11)73373-3"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.2133\/dmpk.DMPK-11-NT-120"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2011.02567.x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34488"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1756-185X.12050","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1756-185X.12050","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.12050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T02:12:20Z","timestamp":1696471940000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.12050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,26]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.1111\/1756-185X.12050"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.12050","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,26]]},"assertion":[{"value":"2013-04-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}