{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:15:20Z","timestamp":1790950520429,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,6,8]],"date-time":"2013-06-08T00:00:00Z","timestamp":1370649600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Korean Ministry of Health and Welfare"},{"name":"Korean Healthcare Technology R&D Project","award":["A102065"],"award-info":[{"award-number":["A102065"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2013,6]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>The aim of this study was to analyze the results of interferon\u2010gamma release assays (IGRA<\/jats:styled-content>s) and tuberculin skin tests (TST<\/jats:styled-content>) performed to detect latent tuberculosis infection (LTBI<\/jats:styled-content>) in patients with rheumatoid arthritis (RA<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>Interferon\u2010\u03b3 release assays and TST<\/jats:styled-content> test results were summarized and systematically reviewed.<\/jats:p><\/jats:sec>Results<\/jats:title>Four hundred and five RA<\/jats:styled-content> patients and 339 controls that underwent IGRA<\/jats:styled-content> and\/or TST<\/jats:styled-content> were identified in seven studies. Five studies were case\u2010control studies and two were cross\u2010sectional studies. Among RA<\/jats:styled-content> patients, the IGRA<\/jats:styled-content> positivity rate was 31.6% (89\/282; range 11.4%\u201344.6%), and the TST<\/jats:styled-content> positivity rate was 23.0% (78\/339; range from 14.60% to 45%). Concordance rates ranged from 40% to 76% and discordance rates from 24% to 29.7%. Agreement between IGRA<\/jats:styled-content>s and TST<\/jats:styled-content> in RA<\/jats:styled-content> was poor (69.6%, k<\/jats:italic>\u00a0=\u00a00.33, 95% CI<\/jats:styled-content> 0.188\u20130.478). The IGRA<\/jats:styled-content> positivity rate was 31.0% in RA<\/jats:styled-content> and 40.0% in controls, which was not significant (relative risk [RR<\/jats:styled-content>] 0.802, 95% CI<\/jats:styled-content> 0.629\u20131.023, P<\/jats:italic>\u00a0=\u00a00.075). The TST<\/jats:styled-content> positivity rate was 24.7% in RA<\/jats:styled-content> and 50.5% in controls, and this difference was not significant (RR<\/jats:styled-content> 0.680, 95% CI<\/jats:styled-content> 0.331\u20131.339, P<\/jats:italic>\u00a0=\u00a00.295).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Positivity rates of IGRA<\/jats:styled-content> and TST<\/jats:styled-content> were 31.6 and 23.0%, respectively, in RA<\/jats:styled-content> patients. Agreement between IGRA<\/jats:styled-content> and TST<\/jats:styled-content> results in RA<\/jats:styled-content> was poor. Our data suggest that both IGRA<\/jats:styled-content> and TST<\/jats:styled-content> are needed to detect LTBI<\/jats:styled-content> in RA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12098","type":"journal-article","created":{"date-parts":[[2013,6,8]],"date-time":"2013-06-08T10:12:40Z","timestamp":1370686360000},"page":"279-283","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Interferon\u2010gamma release assays versus tuberculin skin testing in patients with rheumatoid arthritis"],"prefix":"10.1111","volume":"16","author":[{"given":"Gwan Gyu","family":"Song","sequence":"first","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine Korea University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang\u2010Cheol","family":"Bae","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department 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