{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:29:44Z","timestamp":1761895784965},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,11,15]],"date-time":"2013-11-15T00:00:00Z","timestamp":1384473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate features of urate deposition in gout and the association between these features and attacks of gouty arthritis using dual\u2010energy computed tomography (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Dual\u2010energy <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> scans of both feet were performed in 80 consecutive patients with gout and 22 with asymptomatic hyperuricemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 333 areas of urate deposition were found in patients with gout. The most commonly affected sites were the first metatarsophalangeal joint (<jats:styled-content style=\"fixed-case\">MPJ<\/jats:styled-content>; 57\/333), the distal area of the first toe (59\/333) and the calcaneal bone (61\/333). For episodes of the first <jats:styled-content style=\"fixed-case\">MPJ<\/jats:styled-content> arthritis, urate deposits in the flexor pollicis longus muscle tendon (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.02), as well as solitary and punctate depositions (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.03 and 0.01, respectively) were positively related to the acute attacks. For episodes of arthritis around the ankle, deposits in the area, including the talus and inferior tibia, were associated with attacks of arthritis at the ankle (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.02); additionally, deposits in the flexor tendon adjacent to the inferior tibia (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) and a punctiform conformation were significantly associated with attacks of arthritis (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.02). Logistic regression analysis showed that deposits around the first <jats:styled-content style=\"fixed-case\">MPJ<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a03.38, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.32, 8.17) or around the talus and inferior tibia (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content><jats:italic>\u00a0<\/jats:italic>=\u00a02.83, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.11, 7.15) would increase the risk of an attack of arthritis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Dual\u2010energy <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> imaging can be used to detect and analyze the features of urate deposition in patients with gout. Specific features of the deposits appeared to be associated with acute attacks of gouty arthritis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12194","type":"journal-article","created":{"date-parts":[[2013,11,16]],"date-time":"2013-11-16T05:17:42Z","timestamp":1384579062000},"page":"560-567","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Features of urate deposition in patients with gouty arthritis of the foot using dual\u2010energy computed tomography"],"prefix":"10.1111","volume":"18","author":[{"given":"Ying","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Rheumatology Zhongshan Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Zhongshan Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Radiology Zhongshan Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiyong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Zhongshan Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqin","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Radiology Zhongshan Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianjun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Radiology Zhongshan Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Zhongshan Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hejian","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Huashan Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindi","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Zhongshan Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23176"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39449.819271.BE"},{"key":"e_1_2_6_4_1","first-page":"305","article-title":"Epidemiological study of gout and hyperuricemia in Nanjing","volume":"7","author":"Zhao J","year":"2003","journal-title":"Chin J Dis Control Prev"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-8389(03)00158-1"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem058"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32801450b7"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1368-5031.2006.00853.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22612"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22891"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780390820"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-117184"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2687"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20071087"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.062802"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-007-0802-z"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e3283257b6c"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.09.2428"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0b013e318157a144"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2007.09.016"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/postgradmedj-2012-131000"},{"key":"e_1_2_6_22_1","first-page":"1365","article-title":"Clinical utility of dual\u2010energy CT for evaluation of tophaceous gout","volume":"31","author":"Desai MA","year":"2011","journal-title":"Radio Graphics"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.154054"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780200320"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.2349688"},{"issue":"1","key":"e_1_2_6_26_1","first-page":"34","article-title":"Dual energy CT: added value in gouty arthritis","volume":"96","author":"Spermon J","year":"2013","journal-title":"JBR\u2010BTR"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0b013e31823e5cda"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes308"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3223"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200976"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202786"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-012-0301-3"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-010-0156-4"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1756-185X.12194","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.12194","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1756-185X.12194","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.12194","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T23:11:33Z","timestamp":1696374693000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.12194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,15]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1111\/1756-185X.12194"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.12194","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,15]]},"assertion":[{"value":"2013-11-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}