{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T05:14:46Z","timestamp":1761110086248},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Many studies of human leukocyte antigen (<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>) association with juvenile idiopathic arthritis (<jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>) have reported conflicting results, which were probably related to ethnic differences. Moreover, in India, studies on <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content> typing on <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>, particularly polyarticular <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>, is lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of our study was to reveal the frequency of <jats:styled-content style=\"fixed-case\">HLA DR<\/jats:styled-content> types in a cohort of polyarticular <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> in northern India.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010two polyarticular <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> patients were included as per the recent International League of Associations for Rheumatology classification, 2001. <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content> typing was performed in 21 patients (18 rheumatoid factor [<jats:styled-content style=\"fixed-case\">RF<\/jats:styled-content>]+ and three <jats:styled-content style=\"fixed-case\">RF<\/jats:styled-content>\u2212) by a <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\u2010based polymerase chain reaction method for the determination of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> alleles using sequence specific primers (<jats:styled-content style=\"fixed-case\">SSP<\/jats:styled-content>). The results were compared with that of 23 healthy controls of the same age and sex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>4 was present in five cases (23%) in the diseased group while only in one case (4.3%) in the control group with a relative risk of 5.47, but when compared with only <jats:styled-content style=\"fixed-case\">RF<\/jats:styled-content>+ polyarticular <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>4 was found to be significantly high (27.7% <jats:italic>vs<\/jats:italic>. 4.43%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) with a relative risk of 6.3. Further, <jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>4, <jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>1, <jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>2, <jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>9, <jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>10 were also non\u2010significantly high in these patients with relative risk of 3.2 for <jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>9 and 1.8 for <jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>10. In contrast, <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>6 was seen only in 5.5% of polyarticular <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> cases, whereas it was present in 39% of controls (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), a showing negative association.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>4 codes for susceptibility to <jats:styled-content style=\"fixed-case\">RF<\/jats:styled-content>+ polyarticular <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> with a six\u2010fold risk, whereas <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>6 offers protection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12198","type":"journal-article","created":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T08:42:24Z","timestamp":1383295344000},"page":"268-273","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>HLA<\/scp>\u2010<scp>DR<\/scp> typing in polyarticular juvenile idiopathic arthritis: a study from a tertiary care hospital in northern <scp>I<\/scp>ndia"],"prefix":"10.1111","volume":"17","author":[{"given":"Behera","family":"Dibya Ranjan","sequence":"first","affiliation":[{"name":"Department of Medicine Banaras Hindu University Varanasi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Singh","family":"Nand Kumar","sequence":"additional","affiliation":[{"name":"Department of Medicine Banaras Hindu University Varanasi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Singh","family":"Usha","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunopathology Banaras Hindu University Varanasi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Verma","family":"Pramod Kumar","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunopathology Banaras Hindu University Varanasi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4160-0246-8.50015-2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780331205"},{"key":"e_1_2_7_4_1","first-page":"205","article-title":"HLA associations in juvenile arthritis","volume":"12","author":"Fernandez Vina MA","year":"1994","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_5_1","first-page":"S241","article-title":"HLA\u2010DRB1, DQA1, DQB1 and DPB1 alleles in children with juvenile arthritis from three ethnic groups","volume":"40","author":"Reveilli JD","year":"1997","journal-title":"Arthritis Rheum"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)82541-7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780360406"},{"issue":"10","key":"e_1_2_7_8_1","first-page":"S7","article-title":"Subtypes of Gloria Garavito de Egea Tesis Doctoral 2003 47 HLA\u2010DRB1*03, *08, *11, *12, *13 and *14 in early onset pauciarticular juvenile chronic arthritis (EOPA) with and without iridocyclitis","volume":"12","author":"Haas JP","year":"1994","journal-title":"Clin Exp Rheumatol"},{"issue":"4","key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S0889-857X(21)00130-7","article-title":"The immunogenetics of juvenile rheumatoid arthritis","volume":"17","author":"Nepom B","year":"1991","journal-title":"Rheum Dis Clin North Am"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00307739"},{"issue":"9","key":"e_1_2_7_11_1","first-page":"S37","article-title":"Immunogenetic aspects of juvenile chronic arthritis","volume":"11","author":"Scholz S","year":"1993","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00222468"},{"key":"e_1_2_7_13_1","first-page":"61","article-title":"HLA class I\/class II interaction in EOPA juvenile chronic arthritis","volume":"39","author":"Paul C","year":"1993","journal-title":"Immunogenetics"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00211652"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1995.tb02453.x"},{"key":"e_1_2_7_16_1","first-page":"390","article-title":"International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001","volume":"31","author":"Petty RE","year":"2004","journal-title":"J Rheumatol"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60244-4"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0973-3698(10)60128-8"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111413"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2004.01.016"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1756-185X.12198","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.12198","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T18:04:14Z","timestamp":1695492254000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.12198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1111\/1756-185X.12198"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.12198","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11]]},"assertion":[{"value":"2013-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}