{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T08:39:51Z","timestamp":1765960791979},"reference-count":17,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T00:00:00Z","timestamp":1383004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2017,12]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>Familial Mediterranean fever (FMF<\/jats:styled-content>) is an autosomal recessive autoinflammatory disease characterised by recurrent episodes of fever and polyserositis. To date, insufficient data regarding the prevalence of functional gastrointestinal disorders such as irritable bowel syndrome (IBS<\/jats:styled-content>) and functional dyspepsia (FD<\/jats:styled-content>) have been reported in patients with FMF<\/jats:styled-content>. This study aimed to determine the prevalence of functional gastrointestinal disorders in patients with FMF<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>This study included 122 patients with FMF<\/jats:styled-content> and a control group of 122 healthy volunteers who were similar with respect to age and sex. Clinical data were collected and gastrointestinal complaints were evaluated according to the Rome III<\/jats:styled-content> criteria.<\/jats:p><\/jats:sec>Results<\/jats:title>IBS<\/jats:styled-content> was found in 18% of the patients and 10.7% of the controls (P\u00a0<\/jats:italic>>\u00a00.05). Dyspepsia was reported in 37.7% of the patients and 35.2% of the controls. Constipation was significantly higher in the control group (15.6% vs<\/jats:italic>. 7.4%, P\u00a0<\/jats:italic>=\u00a00.045), whereas diarrhoea was reported significantly more often in patients with FMF<\/jats:styled-content> (P\u00a0<\/jats:italic>=\u00a00.001).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>IBS<\/jats:styled-content> and dyspepsia were not increased in patients with FMF<\/jats:styled-content>, whereas diarrhoea was more frequently reported.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12207","type":"journal-article","created":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T13:37:08Z","timestamp":1383053828000},"page":"2101-2105","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Functional gastrointestinal disorders in patients with familial M<\/scp>editerranean fever"],"prefix":"10.1111","volume":"20","author":[{"given":"Elif","family":"B\u00f6rekci","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Bozok University Faculty of Medicine Yozgat Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Celikbilek","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Bozok University Faculty of Medicine Yozgat Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00fcjde","family":"Soyt\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Dokuz Eyl\u00fcl University Faculty of Medicine Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Servet","family":"Akar","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Dokuz Eyl\u00fcl University Faculty of Medicine Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasan","family":"B\u00f6rekci","sequence":"additional","affiliation":[{"name":"Department of General Surgery Bozok University Faculty of Medicine Yozgat Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilhan","family":"G\u00fcnaydin","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Bozok University Faculty of Medicine Yozgat Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kei279"},{"issue":"9","key":"e_1_2_8_3_1","first-page":"318","article-title":"Familial Mediterranean fever: clinical, molecular and management advancements","volume":"65","author":"Lidar M","year":"2007","journal-title":"Neth J Med"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.211.9"},{"issue":"4","key":"e_1_2_8_5_1","first-page":"S16","article-title":"Plasma and platelet serotonin levels in familial Mediterranean fever","volume":"25","author":"Onat AM","year":"2007","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(04)00726-8"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-007-0132-7"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3182329d9c"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/745829"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090024"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.09.020"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.059"},{"key":"e_1_2_8_13_1","unstructured":"Rome Foundation.Rome III Disorders and Criteria: Rome Foundation. 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