{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T08:23:01Z","timestamp":1722414181753},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,2,8]],"date-time":"2014-02-08T00:00:00Z","timestamp":1391817600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label \/><jats:p>Adalimumab is a fully human, anti\u2010<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content> monoclonal antibody of proven efficacy and safety in the treatment of the signs, symptoms and functional disability of ankylosing spondylitis (<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>). A systematic review and meta\u2010analysis was performed to assess the efficacy and safety of adalimumab treatment, relative to a placebo, in adult patients with <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>. In the efficacy meta\u2010analysis, significantly more patients in the adalimumab group achieved <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ssessment in <jats:styled-content style=\"fixed-case\">AS I<\/jats:styled-content>nternational <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>orking <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>roup (<jats:styled-content style=\"fixed-case\">ASAS<\/jats:styled-content>)20 and <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ath <jats:styled-content style=\"fixed-case\">AS D<\/jats:styled-content>isease <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ctivity <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>ndex (<jats:styled-content style=\"fixed-case\">BASDAI<\/jats:styled-content>)50 compared with patients in the placebo group. Patients in the adalimumab group also showed significant improvement in <jats:styled-content style=\"fixed-case\">BASDAI<\/jats:styled-content> and health\u2010related quality of life. With regard to adverse events, any adverse events and injection\u2010site reaction were significantly higher in the adalimumab group compared with the control group. This meta\u2010analysis shows a higher efficacy of adalimumab relative to placebo, but clinicians should be careful regarding adverse events in adalimumab\u2010treated patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12245","type":"journal-article","created":{"date-parts":[[2014,2,8]],"date-time":"2014-02-08T07:18:50Z","timestamp":1391843930000},"page":"142-148","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Randomized, placebo controlled and double\u2010blind trials of efficacy and safety of adalimumab for treating ankylosing spondylitis: a meta\u2010analysis"],"prefix":"10.1111","volume":"17","author":[{"given":"Hongsheng","family":"Wang","sequence":"first","affiliation":[{"name":"Shanghai 10th People's Hospital Tongji University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongqing","family":"Zuo","sequence":"additional","affiliation":[{"name":"Shanghai 10th People's Hospital Tongji University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengxiong","family":"Sun","sequence":"additional","affiliation":[{"name":"Shanghai 10th People's Hospital Tongji University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingqi","family":"Hua","sequence":"additional","affiliation":[{"name":"Shanghai 10th People's Hospital Tongji University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengdong","family":"Cai","sequence":"additional","affiliation":[{"name":"Shanghai 10th People's Hospital Tongji University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60635-7"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-002-0237-4"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60071-8"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32832c6674"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.8.6.831"},{"key":"e_1_2_6_7_1","first-page":"2225","article-title":"Preliminary core sets for endpoints in ankylosing spondylitis. Assessments in Ankylosing Spondylitis Working Group","volume":"24","author":"der Heijde D","year":"1997","journal-title":"J Rheumatol"},{"key":"e_1_2_6_8_1","first-page":"2286","article-title":"A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index","volume":"21","author":"Garrett S","year":"1994","journal-title":"J Rheumatol"},{"key":"e_1_2_6_9_1","first-page":"295","article-title":"Adalimumab in ankylosing spondylitis: an evidence\u2010based review of its place in therapy","volume":"2","author":"Hennigan S","year":"2007","journal-title":"Core Evid"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.019224"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-002-0261-4"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008996223999"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.9.817"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.040758"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.151563"},{"key":"e_1_2_6_16_1","volume-title":"Review Manager (RevMan) Version 5.1","author":"Cochrane Collaboration","year":"2011"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22887"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1756-185X.2012.01734.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202533"},{"key":"e_1_2_6_20_1","first-page":"2030","article-title":"Beneficial effects of adalimumab on biomarkers reflecting structural damage in patients with Ankylosing spondylitis","volume":"35","author":"Maksymowych WP","year":"2008","journal-title":"J Rheumatol"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201766"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21913"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.082529"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2790"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-009-1111-4"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1699-258X(07)73688-4"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1756-185X.12245","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.12245","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T12:39:33Z","timestamp":1696336773000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.12245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1111\/1756-185X.12245"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.12245","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"2014-02-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}