{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:42:26Z","timestamp":1787013746538,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,1,11]],"date-time":"2014-01-11T00:00:00Z","timestamp":1389398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2017,12]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n \n The exact mechanism of arterial stiffness in fibromyalgia (\n FM<\/jats:styled-content>\n ) remains unclear. The present study aimed to evaluate the association between thyroid function and markers of arterial function in postmenopausal\n FM<\/jats:styled-content>\n patients.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This study included 163 postmenopausal\n FM<\/jats:styled-content>\n patients without any known cardiovascular diseases and within a normal reference range of thyroid\u2010stimulating hormone (\n TSH<\/jats:styled-content>\n ) level. Clinical parameters including the\n F<\/jats:styled-content>\n ibromyalgia\n I<\/jats:styled-content>\n mpact\n Q<\/jats:styled-content>\n uestionnaire (\n FIQ<\/jats:styled-content>\n ), the pain visual analogical scale (\n VAS<\/jats:styled-content>\n ) and tender point counts were measured. Vascular function was assessed by brachial\u2010ankle pulse wave velocity (ba\n PWV<\/jats:styled-content>\n ) and flow\u2010mediated dilation (\n FMD<\/jats:styled-content>\n ). We evaluated the associations between arterial markers and serum\n TSH<\/jats:styled-content>\n , free thyroxin, as well as serum thyroidperoxidase autoantibody (\n TPO<\/jats:styled-content>\n Ab).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Patients with a high ba\n PWV<\/jats:styled-content>\n (\u2265\u00a01490\u00a0cm\/s) showed more positive\n TPO<\/jats:styled-content>\n Ab (65%\n vs<\/jats:italic>\n . 10%,\n P<\/jats:italic>\n \u00a0=\u00a00.006) than those with a normal ba\n PWV<\/jats:styled-content>\n . Additionally, the ba\n PWV<\/jats:styled-content>\n values of patients with positive\n TPO<\/jats:styled-content>\n Ab were significantly different from those with negative\n TPO<\/jats:styled-content>\n Ab. Age,\n FIQ<\/jats:styled-content>\n and\n TPO<\/jats:styled-content>\n Ab were significantly correlated with ba\n PWV<\/jats:styled-content>\n and\n FMD<\/jats:styled-content>\n (all\n P<\/jats:italic>\n \u00a0<\u00a00.05). Multiple linear regression analysis revealed that the only significant predictors of ba\n PWV<\/jats:styled-content>\n were age,\n FIQ<\/jats:styled-content>\n and the presence of\n TPO<\/jats:styled-content>\n Ab after adjustment for traditional risk factors. A significant association was also found between\n FMD<\/jats:styled-content>\n and positive\n TPO<\/jats:styled-content>\n Ab.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Age, functional status and presence of\n TPO<\/jats:styled-content>\n Ab were significantly associated with increased arterial stiffness in postmenopausal\n FM<\/jats:styled-content>\n patients. Given the combined thyroid autoimmunity in\n FM<\/jats:styled-content>\n patients, a re\u2010evaluation of the effects on the vasculature may be necessary.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/1756-185x.12257","type":"journal-article","created":{"date-parts":[[2014,1,11]],"date-time":"2014-01-11T02:15:52Z","timestamp":1389406552000},"page":"1978-1986","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The impact of thyroid autoimmunity on arterial stiffness in postmenopausal patients with fibromyalgia"],"prefix":"10.1111","volume":"20","author":[{"given":"Kyoung Im","family":"Cho","sequence":"first","affiliation":[{"name":"Cardiovascular Research Institute Kosin University School of Medicine Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Maryknoll Medical Center Busan 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