{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T22:06:08Z","timestamp":1780351568885,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,12,14]],"date-time":"2013-12-14T00:00:00Z","timestamp":1386979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and aim<\/jats:title><jats:p>Capable of multi\u2010organ involvement in Sjogren's syndrome (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>), cardiac findings of pulmonary effusion, left ventricular diastolic dysfunction and pulmonary hypertension are seen in patients with <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>. Aortic stiffness (<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>) reflects the mechanical tension and elasticity of the aorta. In this study, our aim is to determine if there is any differences in <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> and left ventricular function between patients diagnosed as <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> and healthy control groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We enrolled 50 patients with <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> and 47 healthy volunteers with similar demographic characteristics. It was found that isovolumetric relaxation time (<jats:styled-content style=\"fixed-case\">IVRT<\/jats:styled-content>) and deceleration time (<jats:styled-content style=\"fixed-case\">DT<\/jats:styled-content>) were significantly longer and early diastolic wave (E) was significantly lower in patients with <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>, but there was no difference in the other parameters. When tissue Doppler echocardiography (<jats:styled-content style=\"fixed-case\">TDE<\/jats:styled-content>) findings were compared between the two groups, it was found that myocardial systolic wave (Sm), myocardial early diastolic wave (Em) and Em\/Am ratio were significantly lower, and myocardial isovolumetric relaxation time (<jats:styled-content style=\"fixed-case\">IVRT<\/jats:styled-content>m) and myocardial performance index (<jats:styled-content style=\"fixed-case\">MPI<\/jats:styled-content>) values were significantly higher in patients with <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>. A significant positive correlations between aortic strain and Sm (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.35, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), Em (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.42, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and Em\/Am (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.26, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.008) and negative correlations in <jats:styled-content style=\"fixed-case\">IVRT<\/jats:styled-content>m (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.36, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and <jats:styled-content style=\"fixed-case\">MPI<\/jats:styled-content> (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.24, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01) were detected. A significant positive correlation between aortic distensibility and Sm (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.36, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), Em (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.44, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), Em\/Am (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.26, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.009) and negative correlation of <jats:styled-content style=\"fixed-case\">IVRT<\/jats:styled-content>m (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.22, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02) were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There is a significant relationship between <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> and left ventricular diastolic dysfunction in patients with <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> in this study. The parameters of aortic elasticity measured by 2D echocardiographic methods can be beneficial in predicting early cardiovascular risk in <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12258","type":"journal-article","created":{"date-parts":[[2013,12,14]],"date-time":"2013-12-14T08:48:39Z","timestamp":1387010919000},"page":"658-663","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Assessment of the relationship between aortic stiffness and left ventricular functions with echocardiography in patients with <scp>S<\/scp>j\u00f6gren's syndrome"],"prefix":"10.1111","volume":"17","author":[{"given":"\u00d6mer F.","family":"\u00c7i\u00e7ek","sequence":"first","affiliation":[{"name":"Department of Cardiology Ankara Ataturk Education and Research Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihal 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